Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

824
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
824
Analgesia and Pain Management01:25

Analgesia and Pain Management

1.4K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.4K
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

760
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
760

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extracellular Vesicle Glial Fibrillary Acidic Protein as a Circulating Biomarker of Traumatic Brain Injury Severity.

Journal of molecular neuroscience : MN·2025
Same author

Optimal Analgesic Volume for Popliteal Plexus Block After Total Knee Arthroplasty: A Blinded RCT Protocol.

Acta anaesthesiologica Scandinavica·2025
Same author

Intraoperative Clonidine in Spine Surgery: A Randomised Controlled Trial.

Acta anaesthesiologica Scandinavica·2025
Same author

The emotional toll of day-of-surgery cancellations on patients - a qualitative study using participant observation and interviews.

International journal of qualitative studies on health and well-being·2025
Same author

Effect of intraoperative methadone in robot-assisted cystectomy on postoperative opioid requirements: A randomized clinical trial.

Acta anaesthesiologica Scandinavica·2024
Same author

Patient-reported harm following cancellation of planned surgery at a Danish university hospital: a cross-sectional study.

BMJ open·2024

Related Experiment Video

Updated: Dec 26, 2025

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

3.4K

Opioid tapering after spine surgery: Protocol for a randomized controlled trial.

Peter Uhrbrand1,2, Anne Phillipsen2, Mikkel M Rasmussen3

  • 1Department of Anaesthesiology and Intensive Care, Aarhus University Hospital, Aarhus, Denmark.

Acta Anaesthesiologica Scandinavica
|March 12, 2020
PubMed
Summary

Post-surgery opioid tapering plans and follow-up can help reduce opioid use in patients. This study investigated the effectiveness of customized tapering plans and telephone counseling for reducing long-term opioid consumption after spine surgery.

More Related Videos

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
04:19

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device

Published on: November 8, 2024

1.0K
Optimizing Minimally Invasive Spine Surgery: A Fully 3D CT O-Arm Navigated Workflow in MIS TLIF
08:34

Optimizing Minimally Invasive Spine Surgery: A Fully 3D CT O-Arm Navigated Workflow in MIS TLIF

Published on: October 17, 2025

277

Related Experiment Videos

Last Updated: Dec 26, 2025

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

3.4K
Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
04:19

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device

Published on: November 8, 2024

1.0K
Optimizing Minimally Invasive Spine Surgery: A Fully 3D CT O-Arm Navigated Workflow in MIS TLIF
08:34

Optimizing Minimally Invasive Spine Surgery: A Fully 3D CT O-Arm Navigated Workflow in MIS TLIF

Published on: October 17, 2025

277

Area of Science:

  • Clinical Medicine
  • Surgical Outcomes
  • Pain Management

Background:

  • Opioid prescriptions are common for patients post-surgery.
  • Many patients continue opioid use after hospital discharge, failing to taper.
  • Effective tapering strategies are needed to manage post-surgical opioid consumption.

Purpose of the Study:

  • To evaluate the impact of customized opioid tapering plans and telephone counseling on post-surgical opioid use.
  • To determine if an intervention reduces the number of patients exceeding preoperative opioid intake.
  • To assess secondary outcomes including withdrawal symptoms and patient satisfaction.

Main Methods:

  • A single-center, randomized controlled trial involving 110 patients undergoing spine surgery.
  • Patients with preoperative opioid use were randomized into an intervention group (tapering plan + telephone counseling) or a control group.
  • The primary outcome was the proportion of patients exceeding preoperative opioid intake one month post-discharge.

Main Results:

  • The study is expected to provide data on the effectiveness of the intervention in reducing opioid consumption.
  • Analysis will focus on the primary outcome and secondary outcomes such as withdrawal symptoms and complete tapering.

Conclusions:

  • The study aims to offer valuable insights into opioid tapering strategies for patients with preoperative opioid use undergoing surgery.
  • Findings could inform clinical practice guidelines for post-operative pain management and opioid stewardship.