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Targeting MYC through WDR5

Lance R Thomas1, Clare M Adams2, Stephen W Fesik3

  • 1Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.

Molecular & Cellular Oncology
|March 12, 2020
PubMed

Insights

The MYC oncoprotein drives cancer but is hard to drug. Disrupting MYC

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • The MYC oncoprotein is overexpressed in many cancers, leading to significant mortality.
  • MYC is a validated anti-cancer target, yet remains undruggable with current therapies.

Purpose of the Study:

  • To investigate the therapeutic potential of inhibiting the MYC oncoprotein.
  • To explore the disruption of the MYC-WD repeat-containing protein 5 (WDR5) interaction as a novel anti-cancer strategy.

Main Methods:

  • Utilized mouse xenograft models to study tumor regression.
  • Focused on breaking the interaction between MYC and its chromatin co-factor WDR5.

Main Results:

  • Disrupting the MYC-WDR5 interaction led to significant tumor regression in preclinical models.
  • This approach provides a new avenue for MYC inhibition.

Conclusions:

  • Targeting the MYC-WDR5 interaction is a promising strategy for cancer therapy.
  • This research lays the groundwork for clinical development of MYC-targeted treatments.
Keywords:
CancerCancer therapyMYCWDR5

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