Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

5.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

10.2K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
10.2K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

5.2K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.2K
Master Transcription Regulators02:23

Master Transcription Regulators

7.6K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.6K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.6K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

4.5K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

5-Azacytidine incorporation into mRNAs disrupts translation and induces ribosome collisions.

bioRxiv : the preprint server for biology·2026
Same author

Identification of KLHL12 Ligands Using Fragment-Based Methods.

Journal of medicinal chemistry·2026
Same author

Discovery of Spiro[chromane-2,4'-piperidine] Derivatives as Irreversible Inhibitors of SARS-CoV-2 Papain-like Protease.

Journal of medicinal chemistry·2026
Same author

Correction to "Fragment-to-Lead Medicinal Chemistry Publications in 2024: A Tenth Annual Perspective".

Journal of medicinal chemistry·2026
Same author

Discovery of Fragment-Based Inhibitors of SARS-CoV-2 PL<sup>Pro</sup>.

Journal of medicinal chemistry·2026
Same author

Fragment-to-Lead Medicinal Chemistry Publications in 2024: A Tenth Annual Perspective.

Journal of medicinal chemistry·2025
Same journal

Mutation detection in women diagnosed with endometrial cancer: a next-generation sequencing analysis.

Molecular & cellular oncology·2026
Same journal

Evolutionary perspectives on endometrial cancer: antagonistic pleiotropy.

Molecular & cellular oncology·2026
Same journal

mRNA vaccines in oncology: personalized cancer immunization and neoantigen targeting.

Molecular & cellular oncology·2026
Same journal

Exploration of the diagnostic and therapeutic potential of the nucleocytoplasmic shuttling protein TMUB1 by inducing G0/G1 cell cycle arrest in ovarian cancer.

Molecular & cellular oncology·2026
Same journal

The LNK adaptor protein: a dual regulator of proliferation and migration in solid tumors.

Molecular & cellular oncology·2026
Same journal

Lactylation-related genes signature panel in hepatocellular carcinoma reveals the prognostic and therapeutic optimization.

Molecular & cellular oncology·2026
See all related articles

Related Experiment Video

Updated: Dec 26, 2025

Wild-type Blocking PCR Combined with Direct Sequencing as a Highly Sensitive Method for Detection of Low-Frequency Somatic Mutations
10:41

Wild-type Blocking PCR Combined with Direct Sequencing as a Highly Sensitive Method for Detection of Low-Frequency Somatic Mutations

Published on: March 29, 2017

12.2K

Targeting MYC through WDR5.

Lance R Thomas1, Clare M Adams2, Stephen W Fesik3

  • 1Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA.

Molecular & Cellular Oncology
|March 12, 2020
PubMed
Summary
This summary is machine-generated.

The MYC oncoprotein drives cancer but is hard to drug. Disrupting MYC

Keywords:
CancerCancer therapyMYCWDR5

More Related Videos

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
11:14

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

1.8K
Focus Formation: A Cell-based Assay to Determine the Oncogenic Potential of a Gene
08:18

Focus Formation: A Cell-based Assay to Determine the Oncogenic Potential of a Gene

Published on: December 31, 2014

28.6K

Related Experiment Videos

Last Updated: Dec 26, 2025

Wild-type Blocking PCR Combined with Direct Sequencing as a Highly Sensitive Method for Detection of Low-Frequency Somatic Mutations
10:41

Wild-type Blocking PCR Combined with Direct Sequencing as a Highly Sensitive Method for Detection of Low-Frequency Somatic Mutations

Published on: March 29, 2017

12.2K
Modeling Paracrine Noncanonical Wnt Signaling In Vitro
11:14

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

1.8K
Focus Formation: A Cell-based Assay to Determine the Oncogenic Potential of a Gene
08:18

Focus Formation: A Cell-based Assay to Determine the Oncogenic Potential of a Gene

Published on: December 31, 2014

28.6K

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • The MYC oncoprotein is overexpressed in many cancers, leading to significant mortality.
  • MYC is a validated anti-cancer target, yet remains undruggable with current therapies.

Purpose of the Study:

  • To investigate the therapeutic potential of inhibiting the MYC oncoprotein.
  • To explore the disruption of the MYC-WD repeat-containing protein 5 (WDR5) interaction as a novel anti-cancer strategy.

Main Methods:

  • Utilized mouse xenograft models to study tumor regression.
  • Focused on breaking the interaction between MYC and its chromatin co-factor WDR5.

Main Results:

  • Disrupting the MYC-WDR5 interaction led to significant tumor regression in preclinical models.
  • This approach provides a new avenue for MYC inhibition.

Conclusions:

  • Targeting the MYC-WDR5 interaction is a promising strategy for cancer therapy.
  • This research lays the groundwork for clinical development of MYC-targeted treatments.