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The elucidation of phospholipid bilayer-small molecule interactions using a combination of phospholipid nanodiscs and
Georgina Townshend1, Gary S Thompson, Lisa J White
1School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK. J.L.Ortega-Roldan@kent.ac.uk.
Chemical Communications (Cambridge, England)
|March 12, 2020
Abstract:
Quantifying phospholipid bilayer-small molecule interactions is vital to the development of new drug candidates and/or medicinal therapies. However, obtaining these data remains problematic. Herein, we detail a phospholipid nanodisc assay which enables the elucidation of these interactions using conventional solution state NMR spectroscopy techniques.
