Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

One-Compartment Model: IV Infusion01:09

One-Compartment Model: IV Infusion

433
Intravenous (IV) infusion is often utilized when continuous and controlled drug delivery is necessary, such as during surgery or in the treatment of chronic diseases. This method offers numerous advantages, including immediate drug action, precise control over dosage, and bypassing the first-pass metabolism.
The one-compartment model for IV infusion uses mathematical equations to describe the rate of change in drug quantity in the body. At steady-state or infusion equilibrium, the drug input...
433
Two-Compartment Open Model: IV Infusion01:15

Two-Compartment Open Model: IV Infusion

503
A two-compartment model is a vital tool in pharmacokinetics, providing an essential understanding of drug behavior, especially for those administered via zero-order intravenous infusion. This model outlines two compartments: the central compartment, where elimination occurs, and the peripheral compartment.
The model illustrates the decrease in plasma drug concentration from the central compartment with a specific equation. It shows that under steady-state conditions, the drug's input rate...
503
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

171
Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
171

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neoadjuvant lenvatinib plus pembrolizumab in Merkel cell carcinoma: an investigator-initiated, open-label phase II trial.

Journal for immunotherapy of cancer·2026
Same author

Metastatic Uveal Melanoma Surveillance: A Delphi Panel Consensus.

Cancers·2026
Same author

ASO Visual Abstract: Recurrence and Survival Outcomes in Patients with Primary Merkel Cell Carcinoma with Positive, Negative or Not Performed Sentinel Lymph Node Biopsy.

Annals of surgical oncology·2025
Same author

ASO Author Reflections: Merkel Cell Carcinoma and Nodal Staging with SLNB.

Annals of surgical oncology·2025
Same author

Recurrence and Survival Outcomes in Patients with Primary Merkel Cell Carcinoma with Positive, Negative, or Not Performed Sentinel Lymph Node Biopsy.

Annals of surgical oncology·2025
Same author

Response to Letter to the Editor Regarding: An Open-Label, Randomized Study of Melphalan/Hepatic Delivery System Versus Best Alternative Care in Patients with Unresectable Metastatic Uveal Melanoma.

Annals of surgical oncology·2025
Same journal

Institutional Learning Curve in Esophagectomy: Technical Standardization of Gastric Conduit Formation and Conduit-Related Outcomes in 187 Consecutive Patients.

Journal of surgical oncology·2026
Same journal

Evaluating the Accuracy of ChatGPT-4o in Addressing Complex Clinical Questions Based on NCCN Guidelines for Rectal Adenocarcinoma.

Journal of surgical oncology·2026
Same journal

Racial Differences in Breast Cancer Treatment and Information Access.

Journal of surgical oncology·2026
Same journal

Comparative Analysis of CEM and Breast MRI: A Retrospective Study.

Journal of surgical oncology·2026
Same journal

The Treatment Efficacy for Patients Undergoing Combined Transanal-Transabdominal Endoscopic Resection of Rectal Anastomosis Stenosis.

Journal of surgical oncology·2026
Same journal

"It Depends on the Situation": Variability in How Surgical Oncologists Elicit and Integrate Patient Values.

Journal of surgical oncology·2026
See all related articles

Related Experiment Video

Updated: Dec 26, 2025

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity
09:38

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity

Published on: January 31, 2025

789

Isolated limb infusion: Institutional protocol and implementation.

Michael J Carr1, James Sun1, Jonathan S Zager1

  • 1Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, Florida.

Journal of Surgical Oncology
|March 13, 2020
PubMed
Summary
This summary is machine-generated.

Isolated limb infusion (ILI) offers a safe and effective treatment for unresectable limb malignancies. This chemotherapy technique isolates the extremity for targeted drug delivery, showing positive outcomes for patients.

Keywords:
in-transit metastasisisolated limb infusionmelphalanregional therapy

More Related Videos

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
09:57

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

Published on: July 13, 2019

13.6K
Porcine Normothermic Isolated Liver Perfusion
07:32

Porcine Normothermic Isolated Liver Perfusion

Published on: June 9, 2023

1.2K

Related Experiment Videos

Last Updated: Dec 26, 2025

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity
09:38

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity

Published on: January 31, 2025

789
A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
09:57

A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit

Published on: July 13, 2019

13.6K
Porcine Normothermic Isolated Liver Perfusion
07:32

Porcine Normothermic Isolated Liver Perfusion

Published on: June 9, 2023

1.2K

Area of Science:

  • Oncology
  • Surgical Oncology
  • Medical Oncology

Background:

  • Unresectable cutaneous and soft tissue malignancies confined to a limb present unique treatment challenges.
  • Multiple therapeutic strategies exist, necessitating evaluation of specific procedural benefits.

Purpose of the Study:

  • To describe the isolated limb infusion (ILI) protocol at Moffitt Cancer Center.
  • To evaluate the safety and efficacy of ILI for limb-confined malignancies.

Main Methods:

  • Detailed description of the ILI protocol.
  • Procedure involves percutaneous catheter placement for isolated extremity perfusion.
  • High-dose chemotherapy administration during the perfusion.

Main Results:

  • Isolated limb infusion (ILI) demonstrated safety in treating patients.
  • ILI proved to be an effective strategy for limb-confined malignancies.
  • Positive outcomes were observed in the patient cohort.

Conclusions:

  • Isolated limb infusion (ILI) is a viable and effective treatment option.
  • The described protocol at Moffitt Cancer Center supports ILI's utility.
  • ILI offers a safe therapeutic approach for unresectable extremity cancers.