Isolated limb infusion: Institutional protocol and implementation

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Updated: Dec 26, 2025

Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity
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Minimally Invasive Isolated Limb Perfusion (MI-ILP) for Locally Advanced Melanomas and Sarcomas of the Extremity

Published on: January 31, 2025

789

Michael J Carr1, James Sun1, Jonathan S Zager1

  • 1Department of Cutaneous Oncology, Moffitt Cancer Center, Tampa, Florida.

Journal of Surgical Oncology
|March 13, 2020
PubMed

Patients with unresectable cutaneous and soft tissue malignancies confined to a limb have many treatment options. Isolated limb infusion (ILI) is one therapeutic option whereby the extremity is isolated and perfused with high-dose chemotherapy through a percutaneously placed catheter-based procedure. A detailed description of the ILI protocol at the Moffitt Cancer Center is given. We have shown that ILI is a safe and effective treatment strategy for malignancies confined to an extremity.

Keywords:
in-transit metastasisisolated limb infusionmelphalanregional therapy

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