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Comorbid disease burden among MS patients 1968-2012: A Swedish register-based cohort study

Kelsi A Smith1, Sarah Burkill2, Ayako Hiyoshi3

  • 1Clinical Epidemiology Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden/Department of Translational Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|March 13, 2020
PubMed
Abstract

Insights

People with multiple sclerosis (pwMS) face a higher risk of comorbid diseases (CMD). While this burden has decreased over time, pwMS still experience a greater CMD prevalence compared to the general population.

Area of Science:

  • Neurology
  • Epidemiology
  • Public Health

Background:

  • People with multiple sclerosis (pwMS) exhibit an elevated risk for comorbid diseases (CMD).
  • Previous research has often overlooked the cumulative burden of CMD in pwMS.

Purpose of the Study:

  • To comprehensively assess the lifetime burden of comorbid diseases among individuals with multiple sclerosis.

Main Methods:

  • A cohort study identified 25,476 pwMS from Swedish registers (1968-2012), matched with 251,170 general population comparators.
  • Prevalence, prevalence ratios (PRs), survival functions, and hazard ratios were analyzed for seven CMD categories (autoimmune, cardiovascular, depression, diabetes, respiratory, renal, seizures) stratified by MS status, age, and time period.

Main Results:

  • The magnitude of PRs for CMD decreased over time, with higher ratios observed in earlier periods.
  • Renal, respiratory, and seizure disorders showed the highest PRs among pwMS.
  • The time gap between initial MS diagnosis and a first/additional CMD diagnosis significantly reduced post-2001, and the relative rate of CMD diagnoses in pwMS decreased over time.

Conclusions:

  • Swedish pwMS demonstrate a significant increase in CMD burden relative to the general population.
  • This CMD burden has shown a reduction trend over recent decades.
Keywords:
Multiple sclerosisSwedenburdenchronic diseasecohortcomorbidityprevalenceregistries

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