Layered self-assemblies for controlled drug delivery: A translational overview.
Apoorva Sarode1, Akshaya Annapragada2, Junling Guo3
1John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; Wyss Institute of Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA.
Biomaterials
|March 13, 2020
Summary
Layer-by-layer (LbL) deposition and other self-assembly techniques offer tunable, multifunctional systems for advanced drug delivery. Innovations are addressing scalability challenges for commercial translation of these smart drug carriers.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Drug Delivery Systems
Background:
- Self-assembly, a natural phenomenon, inspires the development of functional materials for biomedical applications.
- Layered self-assembled systems offer tunability and multifunctionality essential for controlled and targeted drug release.
- Layer-by-layer (LbL) deposition is a key technique for creating tailored layered self-assemblies.
Purpose of the Study:
- To review drug delivery applications utilizing Layer-by-layer (LbL) deposition.
- To discuss scalability challenges and technological innovations for LbL deposition.
- To explore alternative self-assembly techniques like metal-phenolic networks (MPNs) and Liesegang rings for drug delivery.
Main Methods:
- Review of literature on Layer-by-layer (LbL) deposition for drug delivery.
- Analysis of scalability challenges and innovations in self-assembly techniques.
- Examination of metal-phenolic networks (MPNs) and Liesegang rings for controlled drug release.
Main Results:
- Layer-by-layer (LbL) deposition is a versatile technique for creating tunable, multifunctional drug delivery systems.
- Scalability remains a challenge for commercial translation, but technological innovations are emerging.
- Alternative methods like MPNs and Liesegang rings show promise for controlled drug delivery.
Conclusions:
- Self-assembly phenomena, combined with material science advances, can yield powerful, scalable smart drug carriers.
- Further development is needed to overcome scalability hurdles for widespread clinical application of LbL and similar techniques.
- The integration of various self-assembly strategies holds significant potential for next-generation therapeutics.
Keywords:
CommercialLayer-by-layer assemblyLiesegang ringsMetal-phenolic networkPolyelectrolytesTranslationMore Related Videos
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