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Updated: Dec 26, 2025
The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Evaluation of the biological potential of ruthenium(II) complexes with cinnamic acid
Angelica E Graminha1, João Honorato2, Liany Luna Dulcey3
1Departamento de Química, Universidade Federal de São Carlos, CEP 13565-905 São Carlos, SP, Brazil; Departamento de Gerontologia, Universidade Federal de São Carlos, CEP 13565-905 São Carlos, SP, Brazil.
Abstract:
In this work, we present the synthesis and characterization of five new ruthenium compounds with general formula [Ru(L)(dppb)(bipy)]PF6, where L = cinnamic acid derivatives, dppb = 1,4-bis(diphenylphosphino)butane and bipy = 2,2'-bipyridine. The cytotoxicity of the complexes was evaluated against human breast tumor cells from the lines MCF-7, MDA-MB-231 and in human (MCF-10A) or mouse (L929) non-tumor cells. Complexes Ru(L4)(dppb)(bipy)]PF6 (4) (L4 = 4-hydroxycinnamic acid) and [Ru(L5)(dppb)(bipy)]PF6 (5) (L5 = 3,4-dihydroxycinnamic acid) were the most selective, presenting the highest values of selectivity indexes besides inhibited some processes related to tumor progression in vitro, such as invasion, migration, and adhesion in the MDA-MB-231 cell line. In addition, the complexes 4 and 5 were able to interact with Bovine Serum Albumin (BSA) and complex 5 showed antioxidant activity.
