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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
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Long non-coding RNAs regulate drug resistance in cancer
Kaisheng Liu1, Lin Gao1, Xiaoshi Ma1
1The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, 518020, Guangdong, People's Republic of China.
Molecular Cancer
|March 14, 2020
Summary
Long noncoding RNAs (lncRNAs) play a crucial role in cancer chemoresistance. This review details how lncRNAs influence cancer cells
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Chemoresistance presents a significant challenge in cancer therapy.
- Cancer cells develop resistance through diverse molecular mechanisms.
- Long noncoding RNAs (lncRNAs) have emerged as key regulators in cancer progression and drug response.
Purpose of the Study:
- To comprehensively review the literature on the role of lncRNAs in mediating chemoresistance.
- To elucidate the mechanisms by which lncRNAs confer drug resistance or sensitivity in cancer cells.
Main Methods:
- Literature review of recent studies on lncRNAs and chemoresistance.
- Analysis of experimental evidence detailing lncRNA functions in drug resistance.
Main Results:
- lncRNAs are implicated in both intrinsic and acquired chemoresistance.
- Specific lncRNAs have been identified that modulate sensitivity to various chemotherapeutic agents.
- lncRNAs influence multiple cellular pathways involved in drug resistance.
Conclusions:
- lncRNAs are critical mediators of chemoresistance in cancer.
- Targeting lncRNAs presents a promising strategy for overcoming drug resistance.
- Further research into lncRNA functions can lead to novel therapeutic approaches.
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