Related Experiment Video
Updated: Dec 26, 2025
12:08
Improving IV Insulin Administration in a Community Hospital
Published on: June 11, 2012
19.2K
Hypercoagulable State and Glycemic Control in Diabetic Patients with Malignancy
Sry Suryani Widjaja1, Muhammad O K Syahputra1, Almaycano Ginting2
1Biochemistry Department, Medical Faculty, Universitas of Sumatera Utara, Medan, Indonesia.
Open Access Macedonian Journal of Medical Sciences
|March 14, 2020
Summary
Poor glycemic control in diabetic patients with cancer is linked to a hypercoagulable state. This increases the risk of thrombosis, impacting morbidity and mortality in this vulnerable population.
Area of Science:
- Endocrinology
- Oncology
- Hematology
Background:
- Diabetes and malignancy are leading chronic diseases in developing nations, significantly increasing patient morbidity and mortality.
- Diabetes, characterized by hyperglycemia, is associated with an elevated thrombosis risk.
- Cancer is a major cause of death, with thrombosis being a frequent complication due to tumor-induced biological changes, abnormal vascularization, endothelial dysfunction, and inflammation.
Purpose of the Study:
- To investigate the relationship between a hypercoagulable state and glycemic control in diabetic patients diagnosed with malignancy.
Main Methods:
- A case-control study involving eighty diabetic patients (40 with malignancy).
- Data collected from private hospitals and clinics.
- Measurements included Hemoglobin A1c (HbA1c), blood glucose levels, and D-dimer levels.
Main Results:
- 45% of samples exhibited poor blood glucose control.
- Elevated D-dimer levels were observed in both diabetic and diabetic-with-malignancy groups.
- A significant correlation was found between HbA1c and D-dimer (p=0.046), and between blood glucose and age (p=0.017).
Conclusions:
- Chronic hyperglycemia exacerbates the risk of a hypercoagulable state.
- This heightened risk contributes to increased morbidity and mortality in diabetic patients with malignancy.
More Related Videos
Related Concept Videos
01:15Hypoglycemia and Glucagon
727
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
727
01:22Diabetes Mellitus: Type 2 and Gestational
4.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.2K
01:15Diabetes: Management and Pharmacotherapy
786
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
786
01:19Psychoneuroimmunology: Diabetes and Cancer
363
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
363
01:15Diabetes: Symptoms, Diagnosis, and Complications
1.9K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
1.9K
01:22Diabetes Mellitus: Overview and Type I Subtype
4.7K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.7K