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Updated: Dec 26, 2025

Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
Published on: August 22, 2025
Cannabinoid ligands, receptors and enzymes: Pharmacological tools and therapeutic potential
Wafa Hourani1, Stephen P H Alexander1
1School of Life Sciences, Medical School, University of Nottingham, Nottingham, UK.
Abstract:
Endocannabinoids have been identified to have roles in numerous physiological and pathological processes. Largely due to the association of the effects of Cannabis administration on mental states, the CNS impact of the endocannabinoid system has been the most intensively studied. Here, we provide a brief summary of the endocannabinoid system, comprising the receptors and the multiple endogenous lipid derivatives which activate them, as well as the enzymes which control the levels of these lipid derivatives. We identify pharmacological tools which may be used to interrogate the endocannabinoid system, as well as current and future options to exploit the system in the clinic.
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