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Updated: Dec 26, 2025
A Murine Model of Vertical Sleeve Gastrectomy
Published on: December 18, 2017
Percutaneous Closure of Gastrostomy Using a Suture-Mediated Vascular Closure Device in a Swine Model
Euichul Jung1, Sung Bum Cho2, Hyoung Rae Kim3
1Department of Radiology, Eulji University Eulji Hospital, 68, Hangeulbiseok-ro, Nowon-gu, Seoul, 01830, Republic of Korea.
Insights
Immediate closure of percutaneous gastrostomy (PG) sites using Perclose ProGlide devices is feasible and safe. This method prevents complications during tract maturation, as demonstrated in a swine model study.
Area of Science:
- Gastroenterology
- Surgical Innovation
- Medical Device Technology
Background:
- Percutaneous gastrostomy (PG) requires a maturation period of 2-4 weeks.
- Potential complications during this period include tube dislodgement, leakage, and peritonitis.
- Immediate closure of the PG site can prevent these complications.
Purpose of the Study:
- To evaluate the feasibility and safety of immediate percutaneous gastrostomy closure.
- To assess the use of Perclose ProGlide devices for this purpose.
Main Methods:
- A 2-week survival study was conducted in a swine model.
- Perclose ProGlide devices were used to close 13-Fr and 20-Fr PG sites.
- Subjects were monitored for body weight, temperature, and laboratory findings, followed by autopsy and microscopic examination.
Main Results:
- No systemic inflammatory responses were observed in any swine subjects.
- Complete healing of PG sites was observed in five out of six pigs.
- Microscopic examination confirmed complete wound healing at all PG sites.
Conclusions:
- Percutaneous closure of percutaneous gastrostomy sites using single or double Perclose ProGlide devices is feasible.
- The use of Perclose ProGlide for immediate PG closure is safe in a swine model.
Purpose:
After any procedure through the percutaneous gastrostomy (PG), a PG tube should be kept in place until a mature tract develops. For this period of maturation which takes about 2 to 4 weeks, tube dislodgement, leakage, or peritonitis can occur. Complications from PG tube maintenance can be prevented by closing the PG immediately after the procedure. The purpose of this study was to evaluate the feasibility and safety of immediate PG closure using Perclose ProGlide.
Materials And Methods:
A 2-week survival study was performed in a swine model. We applied one Perclose ProGlide device for closing a 13-Fr PG (n = 3) and two devices for closing a 20-Fr PG (n = 3). Body weight, temperature and laboratory findings were observed. Autopsy and microscopic examination were performed after 2 weeks.
Results:
All the swine subjects did not demonstrate any sign of systemic inflammatory responses in terms of fever and laboratory findings. From autopsy results, five pigs showed complete healing of the PG. One pig that underwent 20-Fr gastrostomy site closure with double Perclose ProGlide had scanty semitransparent fluid in the peritoneal cavity but that was not indicative of inflammation. En bloc tissue samples from all the pigs demonstrated complete wound healing of the PG sites.
Conclusion:
Percutaneous application of single or double Perclose ProGlide devices is feasible and safe for the PG closure in a swine model.
Level Of Evidence:
No level of evidence, Animal study.
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