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Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

Diagnostic and Prognostic Non-Invasive Markers in Bladder Cancer.

Ki Choon Sim¹, Min Ju Kim¹, Deuk Jae Sung¹

¹Department of Radiology, Korea University Anam Hospital, Korea University College of Medicine, 73 Goryeodae-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.

Diagnostics (Basel, Switzerland)

|July 15, 2026

Summary

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Non-invasive biomarkers, especially multiparametric MRI (mpMRI) with VI-RADS, show promise for diagnosing and predicting outcomes in bladder cancer, offering an alternative to invasive methods.

Area of Science:

Oncology
Radiology
Urology

Background:

Bladder cancer presents high recurrence and morbidity, with current diagnostic methods like cystoscopy and TURBT being invasive and prone to errors.
Accurate diagnostic and prognostic tools are crucial for managing bladder cancer effectively.
There is a significant need for non-invasive biomarkers to improve bladder cancer detection and management.

Purpose of the Study:

To provide a comprehensive review of current non-invasive diagnostic and prognostic biomarkers for bladder cancer.
To emphasize the role of imaging biomarkers, particularly multiparametric MRI (mpMRI) and VI-RADS.
To discuss the clinical utility, limitations, and future integration of these biomarkers.

Main Methods:

Literature review focusing on non-invasive biomarkers for bladder cancer.

Keywords:

VI-RADS artificial intelligence biomarker bladder cancer liquid biopsy multiparametric MRI non-invasive biomarkers radiomics treatment response urine cytology

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A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

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Last Updated: Jul 16, 2026

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors

Published on: March 29, 2019

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

A Murine Orthotopic Bladder Tumor Model and Tumor Detection System

Published on: January 12, 2017

Emphasis on urine-based assays, blood-based markers, and imaging parameters.

Detailed discussion of multiparametric MRI (mpMRI) and the Vesical Imaging Reporting and Data System (VI-RADS).

Main Results:

Non-invasive biomarkers, including urine and blood assays, offer potential alternatives to invasive procedures.
Multiparametric MRI (mpMRI), assessed by VI-RADS, is a robust non-invasive tool for local staging and risk stratification.
Emerging evidence highlights mpMRI's role in predicting treatment response and recurrence, especially with neoadjuvant therapy.

Conclusions:

Non-invasive biomarkers, particularly mpMRI/VI-RADS, are valuable for bladder cancer diagnosis, staging, and prognosis.
These biomarkers can aid in predicting treatment response and recurrence, complementing traditional methods.
Future integration of non-invasive biomarkers into multimodal decision-making frameworks is essential for improved bladder cancer management.