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Related Experiment Video

Updated: Jan 13, 2026

Application of Microwave Ablation in Laparoscopic Partial Splenectomy
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Radiological Approach to Splenomegaly: Etiologies, Pathophysiologies, and Diagnostic Strategies.

Na Yeon Han1, Yong Park2, Min Ju Kim3

  • 1Department of Radiology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea. mammos@korea.ac.kr.

Korean Journal of Radiology
|January 6, 2026
PubMed
Summary

Splenomegaly, or enlarged spleen, often indicates an underlying condition. Radiologists play a key role in identifying splenomegaly and guiding diagnosis and management.

Keywords:
Differential diagnosisImaging diagnosisLymphomaSpleenSplenomegaly

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Area of Science:

  • Radiology
  • Pathophysiology
  • Abdominal Imaging

Background:

  • The spleen is often overlooked, but splenomegaly (enlarged spleen) is frequently noted in radiological reports.
  • While sometimes idiopathic, splenomegaly commonly signifies an underlying pathological condition.
  • Radiologists are crucial for accurate splenomegaly identification and differential diagnosis.

Purpose of the Study:

  • To provide a comprehensive radiological review of splenomegaly.
  • To categorize causes of splenomegaly based on pathophysiological mechanisms.
  • To enhance diagnostic accuracy and clinical relevance in evaluating splenomegaly.

Main Methods:

  • Comprehensive literature review of splenomegaly.
  • Radiological perspective on diagnosis and etiology.
  • Categorization of causes by pathophysiological mechanisms.

Main Results:

  • Splenomegaly, though often descriptive, frequently indicates underlying pathology.
  • A systematic approach is essential due to diverse etiologies and overlapping imaging features.
  • Categorizing causes aids in accurate diagnosis and management.

Conclusions:

  • Radiologists are instrumental in managing splenomegaly by identifying the condition and guiding workups.
  • A systematic, pathophysiologically-based approach improves diagnostic accuracy for splenomegaly.
  • Understanding the spectrum of splenomegaly causes is vital for effective clinical management.