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A Method for Mouse Pancreatic Islet Isolation and Intracellular cAMP Determination

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Relationship between Free Thyroxine and Islet Beta-cell Function in Euthyroid Subjects.

Qing Li¹, Meng Lu¹, Ning-Jian Wang¹

¹Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China.

Current Medical Science

|March 14, 2020

Summary

This summary is machine-generated.

Even within the normal range, thyroid hormones impact pancreatic islet function. Higher free thyroxine (FT4) levels are independently linked to reduced islet beta-cell function (HOMA-β) in euthyroid individuals, including those with type 2 diabetes.

Keywords:

diabetes euthyroid hormones free thyroxine free triiodothyronine islet beta-cell function

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Area of Science:

Endocrinology
Metabolic Diseases
Diabetes Research

Background:

Thyroid hormones influence glucose metabolism and insulin secretion.
The relationship between thyroid hormone levels and pancreatic islet function in euthyroid individuals requires further investigation, particularly in populations with and without type 2 diabetes mellitus (T2DM).

Purpose of the Study:

To investigate the association between euthyroid thyroid hormone levels and islet beta-cell function (HOMA-β) in the general population and in patients with non-treated type 2 diabetes mellitus (T2DM).

Main Methods:

Cross-sectional study of 5089 euthyroid participants (general population and non-treated T2DM patients) in East China.
Measurement of anthropometric indices, biochemical parameters, and thyroid hormones (TT4, FT4, FT3).
Statistical analysis including correlation, quartile analysis, and linear regression, adjusting for relevant covariates.

Main Results:

Non-treated T2DM patients had higher total thyroxine (TT4) and free thyroxine (FT4) levels but a lower ratio of free triiodothyronine (T3):T4 compared to the general population.
Homeostatic model assessment of beta-cell function (HOMA-β) showed a negative correlation with FT4 and a positive relationship with the free T3:T4 ratio in both groups.
Free thyroxine (FT4) was independently and negatively associated with HOMA-β, irrespective of age, BMI, smoking, hypertension, and lipid profiles.

Conclusions:

Free thyroxine (FT4) is independently and negatively associated with islet beta-cell function in euthyroid subjects.
Thyroid hormone levels, even within the reference range, play a significant role in pancreatic islet function.
Findings suggest a potential link between thyroid hormone status and beta-cell dysfunction in both general and T2DM populations.