Related Experiment Video
Updated: Dec 26, 2025

Screening of Axonal Degeneration in Carpal Tunnel Syndrome Using Ultrasonography and Nerve Conduction Studies
Published on: January 11, 2019
Carpal Tunnel Syndrome as Sentinel for Harmful Hand Activities at Work: A Nationwide Danish Cohort Study
Sorosh Tabatabaeifar1, Susanne Wulff Svendsen, Poul Frost
1Danish Ramazzini Centre, Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark (Dr Tabatabaeifar, Dr Frost), Centre for Integrated Register-Based Research (CIRRAU), Aarhus University, Aarhus, Denmark (Dr Tabatabaeifar), Danish Ramazzini Centre, Department of Occupational Medicine, Regional Hospital West Jutland-University Research Clinic, Herning, Denmark (Dr Tabatabaeifar, Dr Svendsen), Department of Occupational and Environmental Medicine, Bispebjerg Hospital, Copenhagen, Denmark (Dr Svendsen, Dr Frost).
Objective:
Evaluate incidence rates (IRs) of carpal tunnel syndrome (CTS) as sentinels to identify job groups with high hand-wrist exposures.
Methods:
A nationwide register-based cohort study of all born in Denmark. During follow-up 2010 to 2013, we identified first-time CTS diagnoses. We established job groups, calculated sex-specific age-standardized IRs (SIRs) per job group. We linked occupational codes with a job exposure matrix, calculated mean hand load estimate per job group, and plotted hand load against the SIRs.
Results:
We followed 1,171,580 men and 1,137,854 women for 4,046,851 and 3,994,987 person-years; identified 4405 cases among men, 7858 among women; obtained crude IRs of 10.9 and 19.7 per 10,000 person-years. For both sexes, there was a positive association between SIRs and hand load.
Conclusions:
Higher SIRs pointed to job groups with higher hand load. Elevated SIRs of CTS may serve as sentinels of harmful hand activities.

