Related Experiment Video
Updated: Dec 26, 2025

08:57
Myosin-Specific Adaptations of In vitro Fluorescence Microscopy-Based Motility Assays
Published on: February 4, 2021
6.4K
Efficiency of one-dimensional active transport conditioned on motility
1SUPA, School of Physics and Astronomy, University of Edinburgh, Peter Guthrie Tait Road, Edinburgh EH9 3FD, United Kingdom.
Physical Review. E
|March 15, 2020
Summary
Conditioning active matter particles on their motility creates new interactions. This approach enhances energy efficiency, particularly for run-and-tumble particles, revealing potential topological interactions.
Area of Science:
- Statistical Mechanics
- Soft Matter Physics
- Theoretical Physics
Background:
- Stochastic processes exhibit altered properties when conditioned on observable values.
- Active matter systems involve self-propelled particles with inherent motility.
- Dynamical large deviations theory provides tools for analyzing effective processes.
Purpose of the Study:
- To investigate how conditioning interacting self-propelled particles on their motility affects their emergent interactions.
- To analyze the energy efficiency of these conditioned processes.
- To explore the nature of emergent interactions in active matter.
Main Methods:
- Applying the effective process formalism from dynamical large deviations theory.
- Analyzing two models: totally asymmetric exclusion process (TASEP) and run-and-tumble particles.
- Comparing two- and three-body interaction scenarios.
Main Results:
- Conditioning run-and-tumble particles induces alignment interactions and improves efficiency more than in TASEP.
- A diminishing return in efficiency is observed beyond a certain conditioning level.
- A screening effect in three-body systems suggests topological interactions.
Conclusions:
- Conditioning active matter particles on motility can lead to significant energy efficiency gains.
- Exploiting large fluctuations in mobility is key for substantial efficiency improvements.
- Emergent interactions can exhibit topological properties, especially in multi-particle systems.
Related Concept Videos
Active Transport
1.9K
Active transport is a critical biological process that allows cells to move solutes against an electrochemical gradient. This process requires direct energy input and is characterized by its selectivity, saturability, and susceptibility to competitive inhibition.
Primary active transporters, like Na+, K+ and -ATPase, directly utilize ATP to move ions across the membrane. These transporters play significant roles in various physiological processes. For instance, Na+, K+ and -ATPase maintain...
Primary active transporters, like Na+, K+ and -ATPase, directly utilize ATP to move ions across the membrane. These transporters play significant roles in various physiological processes. For instance, Na+, K+ and -ATPase maintain...
1.9K
Drug Absorption Mechanism: Carrier-Mediated Membrane Transport
5.6K
Certain large, lipid-insoluble drug molecules that resemble amino acids, peptides, or glucose, require specialized carrier proteins to facilitate their diffusion across cell membranes. This transport can occur through either facilitated diffusion, which does not require energy input, or active transport, which does require energy input.
Facilitated diffusion is a passive process that utilizes human Solute Carrier (SLC) transporters. These transporters bind to the drug, undergo structural...
Facilitated diffusion is a passive process that utilizes human Solute Carrier (SLC) transporters. These transporters bind to the drug, undergo structural...
5.6K
Primary Active Transport
13.3K
In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction they would...
13.3K
Primary Active Transport
195.4K
In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps that are embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction...
195.4K
Actin Polymerization and Cell Motility
6.3K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
6.3K
Secondary Active Transport
9.1K
One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme "pump" embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
9.1K

