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Fabricating and Labeling Microbubbles with Fluorescent and Radioactive Tracers
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Microbubble Agents: New Directions.

Eleanor Stride1, Tim Segers2, Guillaume Lajoinie2

  • 1Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UK.

Ultrasound in Medicine & Biology
|March 15, 2020
PubMed
Summary
This summary is machine-generated.

Microbubble contrast agents are advancing for diagnostics and therapeutics, including drug delivery. New agents face development and regulatory challenges for clinical use.

Keywords:
Cavitation nucleiMicrobubblesNanodropletsTheranosticUltrasound contrast agents

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Area of Science:

  • Biomedical Engineering
  • Diagnostic Imaging
  • Drug Delivery Systems

Background:

  • Microbubble ultrasound contrast agents have established safety and efficacy in diagnostics.
  • Recent advancements in imaging technology drive the development of new agents.

Purpose of the Study:

  • To review developments in microbubble agents for diagnostic, therapeutic, and theranostic applications.
  • To discuss novel manufacturing techniques and commercial translation challenges.

Main Methods:

  • Review of current literature on microbubble agent development.
  • Analysis of recent clinical trials for therapeutic applications.
  • Examination of manufacturing techniques and regulatory considerations.

Main Results:

  • Established diagnostic applications with ongoing advancements in molecular, 3-D, and super-resolution imaging.
  • Demonstrated therapeutic potential in clinical trials for blood-brain barrier drug delivery and solid tumor treatment.
  • Development of nanoscale precursors for improved circulation and tissue penetration.

Conclusions:

  • Novel microbubble agents show promise for advanced diagnostics and targeted therapies.
  • Significant challenges remain in agent development, manufacturing, and regulatory approval for clinical translation.