Related Experiment Video
Updated: Dec 26, 2025

A Mouse Model of Intestinal Partial Obstruction
Published on: March 5, 2018
Small bowel obstruction caused by intussusception secondary to metastatic melanoma
Abstract:
Small bowel occlusion by intussusception is not common in adults. It may be due tumor lesion such as melanoma metastase. Bowel melanoma can be a primary lesion or metastases of extra-intestinal melanoma. Primary melanoma, originate in mucosal membranes, is very rare in the bowel, but metastatic melanoma, especially localized in the small bowel, is quite common due of the propensity for cutaneous melanoma to metastasis in the gastrointestinal tract. We present a case of a small bowel obstruction by intussusception in a 58 years old woman with previous history of cutaneous melanoma of the head completely excised; she developed a colic abdominal pain 3 weeks before. KEY WORDS: Intussusception, Melanoma metastasis, Small bowel obstruction.
Insights
Adult intussusception is rare and often caused by tumors. This case highlights small bowel obstruction due to melanoma metastasis, a common occurrence in patients with a history of cutaneous melanoma.
Area of Science:
- Gastroenterology and Oncology
Background:
- Small bowel intussusception is uncommon in adults.
- Tumor lesions, particularly melanoma metastases, are a frequent cause of adult intussusception.
- Cutaneous melanoma commonly metastasizes to the gastrointestinal tract, including the small bowel.
Observation:
- A 58-year-old woman with a history of completely excised cutaneous melanoma presented with colic abdominal pain.
- The patient experienced symptoms of small bowel obstruction.
- Intussusception was identified as the cause of the obstruction.
Findings:
- The intussusception was caused by melanoma metastasis to the small bowel.
- This case illustrates a rare presentation of melanoma metastasis.
- Metastatic melanoma is a significant cause of small bowel intussusception in adults.
Implications:
- Highlights the importance of considering metastatic melanoma in adult intussusception cases.
- Underscores the need for thorough patient history, especially in those with prior melanoma.
- Emphasizes the diagnostic challenge and clinical significance of gastrointestinal metastases from cutaneous melanoma.
Related Concept Videos
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Assessment of the Rectum and Anus
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Metastasis
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

