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Comparative study on antidiabetic function of six legume crude polysaccharides
Zhouya Bai1, Jinxia Meng1, Xiaojun Huang1
1State Key Laboratory of Food Science and Technology, China-Canada Joint Lab of Food Science and Technology (Nanchang), Nanchang University, 235 Nanjing East Road, Nanchang 330047, China.
International Journal of Biological Macromolecules
|March 16, 2020
Summary
Red kidney bean polysaccharides show significant potential in managing type II diabetes in mice. These compounds effectively reduced key diabetes markers, outperforming other legume polysaccharides tested.
Area of Science:
- * Nutritional Biochemistry
- * Pharmacology
- * Food Science
Background:
- * Type II diabetes mellitus is a growing global health concern.
- * Dietary components, such as legume polysaccharides, are explored for their therapeutic potential.
- * Understanding the antidiabetic effects of different legume sources is crucial for developing novel treatments.
Purpose of the Study:
- * To compare the antidiabetic efficacy of polysaccharides from six different legumes.
- * To investigate the impact of red kidney bean polysaccharides on metabolic parameters in a type II diabetic mouse model.
- * To correlate chemical composition with observed antidiabetic activity.
Main Methods:
- * Preparation and characterization of polysaccharides from soybean, white kidney bean, red kidney bean, small black soybean, field bean, and lentil.
- * Induction of type II diabetes in mice using a high-fat diet and streptozotocin.
- * Assessment of body weight, fasting blood glucose (FBG), glycosylated serum protein (GSP), HOMA-IR, and blood lipid profiles (TC, TG, LDL-c, HDL-c).
Main Results:
- * Red kidney bean polysaccharides (RK) significantly alleviated emaciation and reduced FBG, GSP, TC, and LDL-c levels.
- * RK demonstrated a notable reduction in triglyceride (TG) and HOMA-IR (p < 0.05).
- * Significant variations in chemical composition (moisture, ash, sugars, phenolics, flavonoids, amino acids, monosaccharides) were observed among the tested legume polysaccharides.
Conclusions:
- * Red kidney bean polysaccharides exhibit superior antidiabetic potential compared to other legume polysaccharides studied.
- * The observed antidiabetic activity of RK is likely attributed to its specific polysaccharide structure and higher content.
- * Legume-derived polysaccharides represent a promising avenue for the management of type II diabetes.
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