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Discrimination between benign and malignant testicular lesions using volumetric apparent diffusion coefficient
Chanyuan Fan1, Xiangde Min1, Zhaoyan Feng1
1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095 Jie Fang Avenue, Hankou, Wuhan, 430030, PR China.
European Journal of Radiology
|March 16, 2020
Summary
Volumetric apparent diffusion coefficient (ADC) histogram analysis can help differentiate benign from malignant testicular masses. Minimum ADC values showed the highest accuracy in this discrimination, aiding in preoperative diagnosis.
Area of Science:
- Radiology
- Oncology
- Medical Imaging
Background:
- Testicular masses require accurate preoperative differentiation between benign and malignant conditions.
- Magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI) is a key modality for evaluating testicular lesions.
Purpose of the Study:
- To assess the utility of volumetric apparent diffusion coefficient (ADC) histogram analysis in distinguishing benign from malignant testicular masses.
- To identify specific ADC histogram parameters that can aid in preoperative diagnosis.
Main Methods:
- Retrospective analysis of 61 pathologically confirmed testicular masses (18 benign, 43 malignant) from 59 patients.
- Preoperative MRI with DWI was performed, and 18 volumetric histogram parameters were extracted from ADC maps.
- Statistical comparisons (t-test/Mann-Whitney U) and receiver operating characteristic (ROC) curve analysis were used to evaluate classification performance.
Main Results:
- Significant differences in ADC histogram parameters were observed between benign and malignant masses.
- Malignant masses showed increased energy, total energy, and range of ADC compared to benign masses.
- Minimum ADC and 10th percentile ADC were significantly reduced in malignant masses, with minimum ADC achieving the highest diagnostic performance (AUC=0.822, sensitivity=81.40%, specificity=77.78%).
Conclusions:
- Volumetric ADC histogram analysis shows promise as a non-invasive tool for preoperative discrimination of testicular masses.
- Minimum ADC value is a particularly effective parameter for differentiating benign from malignant testicular lesions.
