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Related Experiment Video

Updated: Dec 26, 2025

Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System
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Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System

Published on: September 16, 2025

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Endothelial Glycocalyx.

Jan Jedlicka1, Bernhard F Becker2, Daniel Chappell3

  • 1Department of Anaesthesiology, University Hospital of Munich (LMU), Nussbaumstr. 20, Munich 80336, Germany.

Critical Care Clinics
|March 17, 2020
PubMed
Summary
This summary is machine-generated.

The endothelial glycocalyx (EG) is crucial for blood vessel health and its shedding is linked to critical illnesses. Restoring the EG shows promise for patient survival, though clinical application remains challenging.

Keywords:
AKIARDSEndothelial glycocalyxOrgan dysfunctionSeptic injurySheddingTrauma

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Area of Science:

  • Vascular Biology
  • Biomedical Science

Background:

  • The endothelial glycocalyx (EG) is the innermost lining of blood vessels.
  • EG shedding is implicated in critical illnesses, increasing morbidity and mortality.
  • Vessel health is compromised by EG degradation due to disease and medical interventions.

Purpose of the Study:

  • To investigate the role of endothelial glycocalyx (EG) restitution in patient survival.
  • To evaluate the potential of EG reorganization and restitution strategies.

Main Methods:

  • Review of current understanding of endothelial glycocalyx (EG) degradation.
  • Analysis of emerging therapeutic strategies targeting EG repair.

Main Results:

  • Endothelial glycocalyx (EG) degradation is a significant factor in critical illness outcomes.
  • Early-stage trials focusing on EG restitution demonstrate promising results.
  • The transition from laboratory research to clinical practice for EG therapies is substantial.

Conclusions:

  • Restitution of the endothelial glycocalyx (EG) may improve patient survival in critical conditions.
  • Further research and clinical trials are needed to translate EG repair strategies to the bedside.
  • The endothelial glycocalyx (EG) represents a potential therapeutic target for vascular health.