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Updated: Dec 26, 2025

Author Spotlight: High-Sensitivity Tissue Factor Activity Assay for Plasma Diagnosis
Published on: December 29, 2023
Role of Antithrombin III and Tissue Factor Pathway in the Pathogenesis of Sepsis
Sarah Sungurlu1, Jessica Kuppy1, Robert A Balk1
1Division of Pulmonary, Critical Care, and Sleep Medicine, Rush Medical College and Rush University Medical Center, 1725 West Harrison Street, Suite 054, Chicago, IL 606012, USA.
Abstract:
The pathobiology of the septic process includes a complex interrelationship between inflammation and the coagulations system. Antithrombin (AT) and tissue factor are important components of the coagulation system and have potential roles in the production and amplification of sepsis. Sepsis is associated with a decrease in AT levels, and low levels are also associated with the development of multiple organ failure and death. Treatment strategies incorporating AT replacement therapy in sepsis and septic shock have not resulted in an improvement in survival or reversal of disseminated intravascular coagulation.
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