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Choroid plexus papillomas of neonates, infants and children
T Tomita1, D G McLone, A M Flannery
1Division of Pediatric Neurosurgery, Children's Memorial Hospital, Chicago, Ill.
Insights
Choroid plexus papillomas in children are often diagnosed early and surgically removed with no deaths. Most children achieve normal development, but some require shunting for hydrocephalus and may have neurological deficits.
Area of Science:
- Pediatric Neurosurgery
- Pediatric Oncology
- Pediatric Neurology
Background:
- Choroid plexus papillomas (CPPs) are rare tumors typically found in the pediatric population.
- These tumors can cause significant morbidity due to obstructive hydrocephalus.
Purpose of the Study:
- To present a case series of pediatric choroid plexus papillomas.
- To analyze the clinical presentation, management, and outcomes of these tumors in neonates, infants, and children.
Main Methods:
- Retrospective review of 17 pediatric patients diagnosed with choroid plexus papillomas.
- Evaluation included computed tomography (CT) scans.
- All tumors underwent surgical excision and histological verification.
Main Results:
- The majority of patients (82%) were diagnosed and treated within the first 24 months of life.
- Tumor locations varied, with a predilection for the lateral ventricles.
- No surgical or case mortalities occurred; however, 10 patients required permanent shunting for hydrocephalus.
- Long-term follow-up revealed normal neurological and psychomotor development in 13 patients, while 3 experienced developmental delays and seizures, and 1 had hemiparesis.
Conclusions:
- Aggressive surgical resection is crucial for managing pediatric choroid plexus papillomas.
- Appropriate management of associated hydrocephalus is essential for optimizing patient outcomes.
Abstract:
Case descriptions of 17 patients with choroid plexus papillomas of neonates, infants and children are presented. Fourteen (82%) were diagnosed and treated during the first 24 months of life (5 were in the neonatal period). Choroid plexus papillomas were located in the lateral ventricle in 11 (bilateral in 1), the third ventricle in 4, both the lateral and third ventricle in 1 and the fourth ventricle in 1. All patients were evaluated by computed tomography. All tumors were excised and histologically verified. There were no surgical or case mortalities. Ten patients needed permanent shunting postoperatively. Follow-up observations show that 13 patients exhibit normal neurological and psychomotor development. Three are retarded and have seizure disorders. One is hemiparetic but normal otherwise. Aggressive surgical resection and appropriate management of associated hydrocephalus should be performed for the patients with choroid plexus papillomas.