Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Meta-analysis identifies common gut microbiota associated with multiple sclerosis.

Genome medicine·2024
Same author

Identification of commensal gut microbiota signatures as predictors of clinical severity and disease progression in multiple sclerosis.

Scientific reports·2024
Same author

Assessment of dietary intake and its inflammatory potential in persons with pediatric-onset multiple sclerosis.

Multiple sclerosis and related disorders·2024
Same author

Identification of commensal gut microbiota signatures as predictors of clinical severity and disease progression in multiple sclerosis.

medRxiv : the preprint server for health sciences·2023
Same author

Alexander Dalrymple, the Utility of Coral Reefs, and Charles Darwin's Structure and Distribution of Coral Reefs.

Journal of the history of biology·2022
Same author

Serological responses to three doses of SARS-CoV-2 vaccination in inflammatory bowel disease.

Gut·2022

Related Experiment Video

Updated: Dec 26, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

30.9K

The multiple sclerosis gut microbiota: A systematic review.

Ali Mirza1, Jessica D Forbes2, Feng Zhu1

  • 1Djavad Mowafaghian Centre for Brain Health, Faculty of Medicine (Neurology), University of British Columbia, Vancouver, BC, Canada.

Multiple Sclerosis and Related Disorders
|March 17, 2020
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) patients show no significant differences in gut microbiota diversity compared to healthy individuals. However, specific bacterial taxa differ, and immunomodulatory drug exposure may influence gut microbiome composition in MS.

Keywords:
BacteriaGutMicrobiomeMicrobiotaMultiple sclerosisSystematic review

More Related Videos

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method
05:28

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

Published on: May 2, 2022

2.5K
Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

3.3K

Related Experiment Videos

Last Updated: Dec 26, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

30.9K
Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method
05:28

Analysis of Fecal Microbiota Dynamics in Lupus-Prone Mice Using a Simple, Cost-Effective DNA Isolation Method

Published on: May 2, 2022

2.5K
Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

3.3K

Area of Science:

  • Microbiome research
  • Neuroimmunology
  • Gastroenterology

Background:

  • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
  • The gut microbiota's role in MS pathogenesis is increasingly investigated.
  • Understanding gut microbiota composition in MS is crucial for potential therapeutic strategies.

Purpose of the Study:

  • To systematically review and synthesize existing literature on gut microbiota composition in individuals with MS compared to those without MS.
  • To identify consistent patterns in microbial taxonomic differences and diversity metrics between MS patients and controls.
  • To explore the influence of immunomodulatory drug (IMD) exposure on gut microbiota in MS.

Main Methods:

  • Systematic literature search of MEDLINE, EMBASE, and Web of Science databases (2008-2018).
  • Inclusion of case-control studies examining gut microbiota in MS patients and healthy controls.
  • Analysis of data from ten selected studies, totaling 286 MS patients and 296 controls, using various microbial quantification platforms.

Main Results:

  • No significant differences in alpha-diversity were reported in most studies.
  • Two studies reported significant differences in beta-diversity between MS cases and controls.
  • Consistent taxonomic differences observed: lower abundance of Prevotella and Faecalibacterium prausnitzii, higher abundance of Akkermansia muciniphila in MS patients.
  • Immunomodulatory drug exposure was associated with distinct taxonomic differences in three studies.

Conclusions:

  • Gut microbiota diversity does not consistently differ between individuals with and without MS.
  • Specific taxonomic alterations in the gut microbiota are associated with MS.
  • Further longitudinal research is needed to clarify the impact of IMD exposure on gut microbiota composition in MS.