Related Experiment Video
Updated: Dec 26, 2025

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
Published on: February 27, 2016
Sirtuins: potential therapeutic targets for regulating acute inflammatory response?
Vidula Vachharajani1, Charles E McCall2
1Department of Critical Care Medicine/ Respiratory Institute; Inflammation and Immunity/ Lerner Research Institute, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA.
Abstract:
Introduction: Sirtuins are highly conserved nicotinamide adenine dinucleotide (NAD+) sensors that are considered the guardians of homeostasis. Acute inflammation, which is intended to ward off pathogen invasion, is nature's highly conserved stress-associated and molecular-based survival mechanism for most life forms. Acute inflammatory responses deviate cells from the homeostasis to enable survival. It is not surprising perhaps, that these two must interact in the most dramatic way to preserve homeostasis and preserve life.Areas covered: In this review, we present an overview of sirtuin responses in acute life-threatening inflammatory conditions. We examine how the seven sirtuins (sirtuins 1-7) are responsible for modulating the acute inflammatory response in a context-dependent manner, thus presenting novel therapeutic targets. The database search includes Medline (since 1966) and PubMed (since 1996).Expert opinion: Sirtuins fine-tune the inflammatory response to acute infectious and noninfectious inflammatory stimuli. Modulating sirtuin activity leads to profound changes in inflammatory response. Sirtuin-activating and inhibiting agents are emerging as therapeutic agents to resolve inflammation and promote homeostasis in chronic inflammation. The use of sirtuin modulation in acute life-threatening inflammatory conditions has great potential.
Related Concept Videos
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Regulation of the Unfolded Protein Response
NF-κB-dependent Signaling Pathway
NF-κB-dependent Signaling Mechanism
The...
The JAK-STAT Signaling Pathway
Translational Regulation
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

