Involvement of calcium channels in the regulation of adipogenesis

As an important second messenger in adipocytes, calcium ions (Ca²⁺) are essential in regulating various intracellular signalling pathways that control critical cellular functions. Calcium channels show selective permeability to Ca²⁺ and facilitate Ca²⁺ entry into the cytoplasm, which are normally located in the plasmatic and intracellular membranes. The increase of cytosolic Ca²⁺ modulates a variety of signalling pathways and results in the transcription of target genes that contribute to adipogenesis, a key cellular event includes proliferation and differentiation of adipocyte. In the past decades, the involvement of some Ca²⁺-permeable ion channels, such as Ca²⁺ release-activated Ca²⁺ channels, transient receptor potential channels, voltage-gated calcium channels and others, in adipogenesis has been extensively explored. In the present review, we provided a summary of the expression and contributions of these Ca²⁺-permeable channels in mediating Ca²⁺ influxes that drive adipogenesis. Moreover, we discussed their potentials as future therapeutic targets.