Association Between Stroke and Parkinson's Disease: a Meta-analysis
Yumei Liu1, Li Xue2, Yingying Zhang3
1Department of Neurology, Affiliated Hospital of Qingdao University, No. 16 Jiangsu road, Qingdao, 266003, Shandong Province, People's Republic of China.
Journal of Molecular Neuroscience : MN
|March 18, 2020
Summary
This meta-analysis found a significant association between Parkinson's disease (PD) and stroke risk. The findings suggest a potential common pathogenesis and shared preventive strategies for these aging-related neurological disorders.
Area of Science:
- Neurology
- Epidemiology
- Geriatrics
Background:
- Parkinson's disease (PD) and stroke are common aging-related neurological conditions.
- The relationship and co-occurrence of PD and stroke require further clarification due to inconsistent findings in previous research.
Purpose of the Study:
- To conduct a meta-analysis clarifying the association between Parkinson's disease and stroke risk.
- To investigate the pooled risk of stroke in patients with PD.
Main Methods:
- Systematic literature search of PubMed, EMBASE, and Cochrane Library databases (1975-July 2019).
- Inclusion of 13 case-control studies for meta-analysis.
- Sensitivity analysis performed to ensure result robustness.
Main Results:
- A pooled odds ratio (OR) of 1.72 (95% CI 1.19-2.49) for PD in relation to stroke risk.
- An OR of 1.35 (95% CI 1.04-1.74) for cerebral infarct in PD patients.
- An OR of 1.86 (95% CI 1.17-2.98) for stroke pathology in PD patients from postmortem studies.
Conclusions:
- The meta-analysis confirms a significant association between stroke and Parkinson's disease.
- Findings suggest a potential common pathogenesis and shared preventive measures for PD and stroke.
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