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Large Animal Models of Diabetes
Barbara Ludwig1,2,3,4, Eckhard Wolf5, Uwe Schönmann6
1Department of Medicine III, University Hospital Carl Gustav Carus, Dresden, Germany. Barbara.Ludwig@uniklinikum-dresden.de.
Methods in Molecular Biology (Clifton, N.J.)
|March 18, 2020
Summary
Developing safe and reliable large animal diabetes models is crucial for preclinical research. This chapter details pharmacological, surgical, and genetic methods for creating reproducible diabetes models in minipigs and primates.
Area of Science:
- Comparative Medicine
- Endocrinology
- Preclinical Research Models
Background:
- Reliable large animal models are essential for advanced diabetes research.
- Current rodent models face limitations in higher animals, including efficacy and side effects.
- Need for improved, safe, and reproducible diabetes models in species like minipigs and primates.
Purpose of the Study:
- To describe pharmacological and surgical methods for creating diabetes models in minipigs and primates.
- To review genetically modified pig models for diabetes research.
- To ensure safety, reliability, and reproducibility in large animal diabetes modeling.
Main Methods:
- Pharmacological induction of diabetes in large animals.
- Surgical induction of diabetes in large animals.
- Development and application of genetically modified pig models.
Main Results:
- Established protocols for pharmacological and surgical diabetes induction in minipigs and primates.
- Demonstrated the utility of genetically modified pigs for diabetes research.
- Highlighted safety and reproducibility of described methods.
Conclusions:
- Pharmacological and surgical approaches offer reproducible and safe methods for large animal diabetes models.
- Genetically modified pigs provide a valuable alternative for diabetes research.
- These models are critical for advancing preclinical diabetes studies.
