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Updated: Dec 26, 2025

Intact Histological Characterization of Brain-implanted Microdevices and Surrounding Tissue

Intact Histological Characterization of Brain-implanted Microdevices and Surrounding Tissue

Published on: February 11, 2013

Microphysiological Systems: A Pathologist's Perspective.

Radhakrishna Sura¹, Terry Van Vleet¹, Brian R Berridge²

¹Global Preclinical Safety, AbbVie Inc, North Chicago, IL, USA.

Veterinary Pathology

|March 18, 2020

Summary

This summary is machine-generated.

Microphysiological systems (MPS), or organs-on-chips, offer advanced in vitro modeling for drug discovery. Early pathologist involvement is key to developing more predictive and human-relevant MPS models.

Keywords:

alternative biomarker cell culture techniques drug development in vitro induced pluripotent stem cells microphysiological system model organ on a chip safety assessment

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Last Updated: Dec 26, 2025

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Published on: October 28, 2018

Area of Science:

Biomedical Engineering
Drug Discovery
Toxicology

Background:

Current in vitro models lack human-relevant complexity, limiting their predictive power for in vivo responses.
Microphysiological systems (MPS) aim to improve in vitro modeling for research and drug development.
Existing MPS models often lack full characterization of cellular complexity and attributes.

Purpose of the Study:

To provide an overview of microfluidic MPS (organs-on-chips) capabilities and limitations in drug development.
To highlight the importance of interdisciplinary collaboration in developing reliable MPS.
To recommend strategies for enhancing MPS model predictivity.

Main Methods:

Review of microfluidic microphysiological systems (MPS) for drug development.
Analysis of current MPS capabilities and limitations.
Discussion of the role of pathologists in MPS development.

Main Results:

MPS represent a significant advancement over traditional in vitro models.
Incomplete characterization of cellular complexity and attributes is a key limitation of current MPS.
Early engagement of pathologists can improve MPS model robustness.

Conclusions:

Microfluidic MPS offer revolutionary potential for in vitro modeling in drug discovery.
Pathologist involvement is crucial for developing comprehensive and predictive MPS models.
Enhanced MPS models can more accurately replicate human biology and pathophysiology, improving response prediction.