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[Anicteric cholestasis: a rare hepatic dysfunction caused by hyperthyroidism].

Dayssem Khelifi1, Ibtissem Ben Nacef1, Imen Rojbi1

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This study reports a rare case of liver dysfunction, specifically anicteric cholestasis, in a patient with Graves' disease. The liver issues resolved after treating the hyperthyroidism, highlighting a potential link between thyroid health and liver function.

Keywords:
Anicteric cholestasisGraves’ diseasehyperthyroidism

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Area of Science:

  • Endocrinology
  • Hepatology
  • Internal Medicine

Background:

  • Thyroid disease encompasses diverse clinical and visceral manifestations.
  • Hepatic involvement in thyroid disorders is infrequently documented.
  • Graves' disease, an autoimmune condition, primarily affects the thyroid gland.

Observation:

  • A 50-year-old patient with Graves' disease, lacking goiter or ocular symptoms, was monitored.
  • Routine laboratory tests revealed anicteric cholestasis (jaundice-free liver dysfunction).
  • Initial investigations for other causes of cholestasis were inconclusive.

Findings:

  • Liver parameters normalized following treatment for hyperthyroidism.
  • This outcome strongly suggested a causal link between Graves' disease and the hepatic manifestation.
  • The specific hepatic issue identified was anicteric cholestasis.

Implications:

  • This case underscores the importance of considering hepatic involvement in patients with thyroid disease, even without typical symptoms.
  • It highlights anicteric cholestasis as a rare but potential manifestation of Graves' disease.
  • Further research may elucidate the mechanisms connecting thyroid dysfunction and liver pathology.