[Correlations between lysosomal enzymes and cyclic nucleotides during allergies in children]

Correlation between activity of beta-galactosidase, N-acetyl-beta-D-glucosaminidase and content of cAMP and cGMP was studied in lymphocytes and polymorphonuclear leukocytes obtained from 20 children with atopic form of bronchial asthma and 9 patients with dermorespiratory syndrome. Activity of the lysosomal hydrolases studied correlated distinctly with the content of cyclic nucleotides in the leukocytes and lymphocytes of children with bronchial asthma and dermorespiratory syndrome. The most distinct relationship was found between the eosinophilia, the enzymatic activity and the cGMP content in lymphocytes and neutrophils under conditions of dermorespiratory syndrome. The data obtained suggest the dissimilarity of regulatory effects of cyclic nucleotides on functional activity of lysosomes in leukocytes of children with atopic form of bronchial asthma and dermorespiratory syndrome.