[Changes in cholesterol level and binding in guinea pig tissues during ethanol intoxication and cholesterolemia]

Content of cholesterol and binding of its labelled analogue was studied in guinea pigs tissues after hypercholesterolemia, ethanol intoxication and their combined action within 30, 60 and 90 days. Long-term consumption of cholesterol and chronic alcoholization caused accumulation of the steroid but in abundance of exogenous cholesterol its concentration was increased mainly in liver tissue and blood serum, whole in ethanol intoxication--in brain and kidney tissues. Chronic alcoholization contributed to cholesterosis development; the increase in cholesterol content was accompanied by a decrease in its renovation, especially distinct in liver and heart tissues. Combined effect of cholesterol and ethanol on liver tissue was detected within 60 days; at the same time, simultaneous effect of cholesterol and ethanol caused more pronounced impairments in liver tissue within 90 days as compared with the individual action of these drugs. Concentration of cholesterol was not altered in heart muscle after administration either cholesterol or ethanol, while its content was increased after the drugs simultaneous effect.