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Updated: Dec 26, 2025

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

Published on: April 4, 2017

Metabolic mapping with plasmonic nanoparticle assemblies.

Nguyen H Le¹, Gang Ye, Chun Peng

¹Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3, Canada. jilchen@yorku.ca.

|March 18, 2020

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A novel stick-and-peel plasmonic sensing platform enables label-free biomolecular analysis of single cells and their microenvironments. This economical technology maps local target concentrations, offering potential for on-site molecular pathology.

Area of Science:

Nanotechnology
Biomolecular Analysis
Plasmonics

Background:

Single-cell analysis is crucial for understanding cellular heterogeneity and disease.
Current methods often involve complex labeling, purification, and separation steps.
There is a need for rapid, simple, and cost-effective analytical platforms.

Purpose of the Study:

To develop a novel stick-and-peel plasmonic sensing platform for label-free biomolecular analysis.
To demonstrate the platform's capability in mapping intracellular targets and microenvironments.
To assess the potential for clinical applications such as on-site molecular pathology.

Main Methods:

Utilized substrate-bound plasmonic gold nanoparticle assemblies linked by reconfigurable oligonucleotides.

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Published on: September 27, 2011

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Plasmonic Trapping and Release of Nanoparticles in a Monitoring Environment

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Target binding induced disassembly of nanoparticle assemblies.

Monitored changes in light scattering intensity of discrete nanoparticle assemblies to map local target concentrations.

Applied the platform for quantifying intracellular ATP levels in ovarian cancer cell lines.

Main Results:

Successfully developed a rapid and simple stick-and-peel plasmonic sensing methodology.
The platform is label-free, purification-free, and separation-free.
Quantified intracellular ATP levels in two ovarian cancer cell lines, revealing differences and cellular distribution.
Demonstrated the platform's utility in mapping the microenvironment of a 2D heterogeneous surface.

Conclusions:

The stick-and-peel plasmonic sensing platform offers a powerful tool for single-cell and microenvironment biomolecular analysis.
The portable and economical nature of the platform can enhance the affordability and applicability of single-cell analyses.
This technology holds significant promise for advancing clinical care, particularly in on-site molecular pathology.