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Related Experiment Video

Updated: Jul 9, 2026

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
10:05

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Published on: April 28, 2015

A modular microfluidic chip unit for multiple-organ-on-chip platform integration and drug screening.

Yun-Jie Hao1, Jui-Wei Chen1, Yi-Wun Ke1

  • 1Department of Engineering and System Science, National Tsing Hua University, Hsinchu, Taiwan. fangang@ess.nthu.edu.tw.

The Analyst
|July 8, 2026
PubMed
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A novel modular multi-organ-on-a-chip platform enables dynamic study of drug responses. This system mimics inter-organ crosstalk, reducing the need for animal models in pharmaceutical research.

Area of Science:

  • Biotechnology
  • Pharmacology
  • Microfluidics

Background:

  • Organ-on-chip systems offer in vitro drug testing alternatives to animal models.
  • In vivo organs are separated by barriers but connected via circulation.
  • Existing platforms lack modularity for complex inter-organ studies.

Purpose of the Study:

  • To develop a reconfigurable microfluidic chip array for a multi-organ-on-a-chip (MoC) platform.
  • To enable the study of inter-organ crosstalk and systemic drug responses.
  • To provide a scalable alternative to animal testing in drug development.

Main Methods:

  • Designed a modular, bicompartmental microfluidic chip unit with integrated microchannels.
  • Developed a system for static or dynamic perfusion within chip units.

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Related Experiment Videos

Last Updated: Jul 9, 2026

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture
10:05

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Published on: April 28, 2015

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips
14:44

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

Generation of a Human iPSC-Based Blood-Brain Barrier Chip
10:20

Generation of a Human iPSC-Based Blood-Brain Barrier Chip

Published on: March 2, 2020

  • Assembled units into linear and matrix arrays for high-throughput and systemic analysis.
  • Constructed a liver-tumour MoC model to investigate inter-organ interactions.

    • Main Results:

    • Demonstrated significant alteration in drug efficacy and toxicity by varying liver-to-tumour cell ratios.
    • Confirmed inter-organ crosstalk influencing drug responses in the MoC model.
    • Validated the platform's capability for studying systemic drug effects.

    Conclusions:

    • The modular MoC platform facilitates scalable research on systemic drug responses and inter-organ interactions.
    • This technology shows strong potential to reduce reliance on animal models in pharmaceutical research.
    • The reconfigurable design supports diverse experimental setups for drug discovery and toxicology.