Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

40.1K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A closed-loop cell therapy engineered to autonomously secrete activin A inhibitor protects from fibrodysplasia ossificans progressiva.

iScience·2026
Same author

K-attention: a biologically informed attention operator for data-efficient sequence-based omics modeling.

Briefings in bioinformatics·2026
Same author

Negative Pressure Wound Therapy for the Prevention of Wound Complications After Hepatopancreatobiliary Surgery: A Systematic Review and Meta-Analysis.

Health science reports·2026
Same author

FGO-SLAM++: Real-time Geometry-Aware Gaussian SLAM with Continuous Opacity Field.

IEEE transactions on visualization and computer graphics·2026
Same author

Ubiquitination in ischemic stroke: Molecular mechanisms and therapeutic implications.

Brain research bulletin·2026
Same author

Corrigendum to 'Wavelength-dependent photobiomodulation attenuates synovial inflammation in fibroblast-like synoviocytes and a collagenase-induced osteoarthritis model' [Journal of Photochemistry & Photobiology B: Biology Volume 272 (2025) 113276].

Journal of photochemistry and photobiology. B, Biology·2026

Related Experiment Video

Updated: Dec 26, 2025

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
08:28

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling

Published on: May 21, 2020

7.2K

An Implanted Magnetic Microfluidic Pump for In Vivo Bone Remodeling Applications.

Ziyu Chen1, Sunggi Noh2, Rhonda D Prisby2

  • 1Department of Electrical Engineering, The University of Texas at Dallas, Richardson, TX 75080, USA.

Micromachines
|March 19, 2020
PubMed
Summary

Researchers developed an implantable magnetic microfluidic pump to modulate fluid flow in bone. This device wirelessly delivers controlled pressure to the bone intramedullary cavity, aiding bone growth studies.

Keywords:
implantableintramedullary cavitymagneticmicrofluidic pump

More Related Videos

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

12.1K
A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
09:07

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Published on: December 16, 2022

3.7K

Related Experiment Videos

Last Updated: Dec 26, 2025

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
08:28

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling

Published on: May 21, 2020

7.2K
Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

12.1K
A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
09:07

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Published on: December 16, 2022

3.7K

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Biomaterials

Background:

  • Fluid flow modulation in bone intramedullary cavities stimulates cellular activity and bone growth.
  • Previous studies were limited by external pumps and transcutaneous tubing.
  • A need exists for minimally invasive methods to study in vivo fluid dynamics in bone.

Purpose of the Study:

  • To develop and characterize an implantable magnetic microfluidic pump for in vivo bone studies.
  • To assess the wireless actuation and pressure delivery capabilities of the device.
  • To evaluate the pump's efficacy in modulating fluid pressure within a rodent's femoral intramedullary cavity.

Main Methods:

  • Fabrication of a compact polydimethylsiloxane (PDMS) microfluidic pump with NdFeB magnets.
  • Utilized an external actuator with a larger magnet for wireless pump operation.
  • Characterized static and dynamic pressures of the pump.
  • Implanted the pump into Fischer-344 rats and connected it to the femur's intramedullary cavity.

Main Results:

  • Successfully fabricated a compact (22 mm diameter, 5 mm thickness) implantable magnetic microfluidic pump.
  • Demonstrated wireless, on-demand actuation of the pump using an external magnetic actuator.
  • Achieved fluid pressure modulation up to 38 mmHg within the rat's femoral intramedullary cavity.

Conclusions:

  • The developed implantable magnetic microfluidic pump offers a novel, minimally invasive tool for in vivo bone fluid flow modulation.
  • This technology facilitates the study of bone mechanobiology and growth stimulation in a more natural physiological environment.
  • The wireless actuation and controlled pressure delivery open new avenues for therapeutic interventions targeting bone regeneration.