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Updated: Dec 26, 2025

SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer
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SUMO-Binding Entities SUBEs as Tools for the Enrichment, Isolation, Identification, and Characterization of the SUMO Proteome in Liver Cancer

Published on: November 1, 2019

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The implication of the SUMOylation pathway in breast cancer pathogenesis and treatment

Andrea Rabellino1, Kum Kum Khanna1

  • 1QIMR Berghofer Medical Research Institute, Brisbane City, Australia.

Critical Reviews in Biochemistry and Molecular Biology
|March 19, 2020
PubMed

Insights

SUMOylation, a key protein modification, is frequently altered in breast cancer. Understanding its role in tumorigenesis may offer new therapeutic strategies for breast cancer patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Breast cancer is a leading cause of cancer death globally.
  • Cellular transformation involves genomic and proteomic alterations, including post-translational modifications (PTMs).
  • PTMs regulate protein activity, and their deregulation can drive tumorigenesis.

Purpose of the Study:

  • To review the role of SUMOylation in breast cancer development.
  • To explore the implications of SUMOylation deregulation in breast tumorigenesis.
  • To discuss the potential of targeting SUMOylation pathways for breast cancer therapy.

Main Methods:

  • Literature review of studies on SUMOylation and breast cancer.
  • Analysis of the involvement of SUMOylation in critical cellular processes.
  • Examination of evidence linking SUMOylation pathway alterations to breast cancer progression.

Main Results:

  • SUMOylation is a crucial PTM involved in cell cycle regulation, protein trafficking, and DNA repair.
  • Deregulation of the SUMOylation pathway is observed in various human pathologies, including breast cancer.
  • Altered SUMOylation contributes to abnormal cell proliferation during breast tumorigenesis.

Conclusions:

  • SUMOylation plays a significant role in breast cancer initiation and progression.
  • The SUMOylation pathway represents a potential therapeutic target for breast cancer treatment.
  • Further research into SUMOylation in breast cancer may lead to novel therapeutic strategies.
Keywords:
Cell cycleDNA damage repairSUMOylationbreast cancer

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