Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Role of Hippocampus in Memory

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Base editing in rice using nuclease-deactivated CRISPR/Cas-SF01.

Journal of integrative plant biology·2026

Same author

Systemic gas embolism in three cases of CT-guided percutaneous lung puncture under general anesthesia: case reports and literature review.

Frontiers in medicine·2026

Same author

Genetically encoded fluorescent reporters to visualize α-synuclein pathology in live brain.

Cell·2026

Same author

Modeling and Mechanistic Analysis of Molten Pool Evolution and Energy Synergy in Laser-Cold Metal Transfer Hybrid Additive Manufacturing of 316L Stainless Steel.

Materials (Basel, Switzerland)·2026

Same author

A molecularly defined brain circuit module for regulating panic-like defensive state.

Nature communications·2025

Same author

Androgen receptors in corticotropin-releasing hormone neurons mediate the sexual dimorphism in restraint-induced thymic atrophy.

Proceedings of the National Academy of Sciences of the United States of America·2025

Search research articles

Related Experiment Video

Updated: Dec 26, 2025

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

Conditional Dnmt3b deletion in hippocampal dCA1 impairs recognition memory.

Qingnuan Kong^1,2, Ming Yu¹, Meng Zhang¹

¹Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Qingdao University, Qingdao, 266071, Shandong, China.

Molecular Brain

|March 19, 2020

Summary

DNA methyltransferase 3 beta (DNMT3B) in the hippocampus is crucial for specific recognition memory. Conditional deletion of DNMT3B impaired novel object-place recognition, highlighting its role in memory processes.

Keywords:

Dnmt3b Hippocampus Memory Object-place recognition

More Related Videos

Dissection of Hippocampal Dentate Gyrus from Adult Mouse

Dissection of Hippocampal Dentate Gyrus from Adult Mouse

Published on: November 17, 2009

Assessment of Dendritic Arborization in the Dentate Gyrus of the Hippocampal Region in Mice

Assessment of Dendritic Arborization in the Dentate Gyrus of the Hippocampal Region in Mice

Published on: March 31, 2015

Related Experiment Videos

Last Updated: Dec 26, 2025

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

Dissection of Hippocampal Dentate Gyrus from Adult Mouse

Dissection of Hippocampal Dentate Gyrus from Adult Mouse

Published on: November 17, 2009

Assessment of Dendritic Arborization in the Dentate Gyrus of the Hippocampal Region in Mice

Assessment of Dendritic Arborization in the Dentate Gyrus of the Hippocampal Region in Mice

Published on: March 31, 2015

Area of Science:

Neuroscience
Epigenetics
Molecular Biology

Background:

Neuronal DNA methylation and demethylation regulate synaptic plasticity and memory formation.
DNA methyltransferases (DNMTs) are key enzymes in DNA methylation.
Previous work highlighted roles for DNMT1 and DNMT3a in memory.

Purpose of the Study:

To investigate the role of DNMT3B in memory processes.
To explore DNMT3B-mediated DNA methylation in learning and memory.

Main Methods:

Conditional knockdown of DNMT3B in dorsal CA1 hippocampal neurons of adult mice using AAV-syn-Cre-GFP.
Behavioral tests (novel object recognition and novel object-place recognition) to assess memory.
Gene expression analysis (microarray and qRT-PCR) to identify differentially expressed genes.

Main Results:

Conditional DNMT3B deletion impaired novel object-place recognition but not novel object recognition.
Microarray analysis revealed differential expression of K+ channel subunits, including increased Kcne2.
NPR training induced hippocampal DNMT1 and DNMT3a mRNA upregulation in controls, but not in DNMT3B-deleted mice.

Conclusions:

Conditional DNMT3B deletion in a specific hippocampal sub-region impairs hippocampus-dependent recognition memory.
DNMT3B plays a critical role in specific forms of memory, potentially through regulating ion channel gene expression.