Ginger in patients with active ulcerative colitis: a study protocol for a randomized controlled trial
Forough Shayesteh1, Fatemeh Haidari2, Ali Akbar Shayesteh3
1Department of Nutrition, Nutrition, and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Trials
|March 19, 2020
Summary
This study investigates ginger supplementation for active ulcerative colitis (UC), an inflammatory bowel disease. Findings will reveal ginger
Area of Science:
- Gastroenterology and Hepatology
- Natural Product Chemistry
- Clinical Trial Research
Background:
- Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) significantly impacting patient quality of life.
- Current UC treatments have limitations and side effects, necessitating exploration of alternative therapies.
- Ginger and its active compounds exhibit promising antioxidant, anti-inflammatory, and anti-ulcerative properties in preclinical studies.
Purpose of the Study:
- To evaluate the efficacy of ginger supplementation as an adjunct therapy for active ulcerative colitis.
- To assess the impact of ginger on key inflammatory markers and oxidative stress in UC patients.
Main Methods:
- A 12-week, double-blind, randomized controlled trial (RCT) involving 44 patients with active UC.
- Participants were randomized into two groups: one receiving standard treatment plus ginger capsules, the other receiving standard treatment plus placebo capsules.
- Primary outcome measures included changes in inflammatory markers (TNF-α, hs-CRP) and total antioxidant capacity.
Main Results:
- Data analysis is pending.
- The study is registered under IRCT20190129042552N1.
Conclusions:
- The trial is expected to provide clinical evidence regarding the therapeutic potential of ginger supplementation in managing active ulcerative colitis.
- Results will inform future research and clinical practice for UC management.
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