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m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer
Huilin Huang1, Hengyou Weng2, Jianjun Chen3
1Department of Systems Biology & the Gehr Family Center for Leukemia Research, the Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
Cancer Cell
|March 19, 2020
Summary
N6-Methyladenosine (m6A) RNA modification regulates gene expression and impacts cancer development. Targeting m6A regulators offers potential for novel cancer therapies.
Area of Science:
- Molecular Biology
- Epigenetics
- Cancer Research
Background:
- N6-Methyladenosine (m6A) is a reversible epigenetic modification crucial for gene expression regulation in eukaryotes.
- m6A modifications are found in both coding and non-coding RNAs, influencing RNA fate and vital biological processes.
- m6A plays significant roles in cancer development and progression.
Purpose of the Study:
- To review current knowledge on the pathological roles of m6A modifications in cancer.
- To elucidate the molecular mechanisms underlying m6A's involvement in cancer pathogenesis.
- To discuss the therapeutic potential of targeting m6A regulators in cancer treatment.
Main Methods:
- Literature review of up-to-date research on m6A RNA modifications in cancer.
- Analysis of m6A's roles in both coding and non-coding RNAs.
- Exploration of m6A's impact on cancer drug response and resistance.
Main Results:
- m6A modifications are implicated in various aspects of cancer pathogenesis.
- m6A regulators influence cancer development through diverse molecular pathways.
- m6A alterations are linked to cancer drug response and resistance.
Conclusions:
- m6A RNA modifications are critical players in cancer biology.
- Targeting m6A regulators presents a promising therapeutic strategy for cancer treatment.
- Further research into m6A mechanisms can lead to innovative cancer therapies.
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