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Non-invasive Assessment of Microvascular and Endothelial Function
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Quantitative and Dynamic MRI Measures of Peripheral Vascular Function.

Erin K Englund1, Michael C Langham2

  • 1Department of Orthopaedic Surgery, University of California, San Diego, La Jolla, CA, United States.

Frontiers in Physiology
|March 19, 2020
PubMed
Summary
This summary is machine-generated.

Quantitative magnetic resonance imaging (MRI) methods can detect endothelial dysfunction, a key factor in vascular diseases. These non-contrast MRI techniques offer new ways to assess vascular health and disease progression.

Keywords:
MRIblood flowendothelial (dys)functionflow mediated dilatationperfusionreactive hyperemia

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Area of Science:

  • Cardiovascular Research
  • Medical Imaging
  • Physiology

Background:

  • Endothelial dysfunction is a primary driver of vascular diseases like atherosclerosis.
  • Assessing peripheral vascular function is crucial for early disease detection.
  • Current methods for evaluating vascular function have limitations.

Purpose of the Study:

  • To review advancements in non-contrast, proton magnetic resonance imaging (MRI) for quantifying dynamic blood flow and oxygenation.
  • To highlight the utility of quantitative MRI in detecting endothelial dysfunction.
  • To explore the potential clinical applications of these MRI techniques.

Main Methods:

  • Review of quantitative MRI techniques including BOLD, ASL, PC-MRI, high-resolution MRI, and dynamic MR oximetry.
  • Focus on non-contrast proton MRI methods for dynamic blood flow and oxygenation quantification.
  • Summarizing methodologic principles for each MRI technique.

Main Results:

  • Quantitative MRI methods can dynamically assess blood flow and oxygenation.
  • These techniques detect endothelial dysfunction in patients with cardiovascular disease and in sub-clinical settings (e.g., smokers, e-cigarette users, age-related changes).
  • MRI-derived vascular function measures show promise as biomarkers for disease progression and treatment response.

Conclusions:

  • Dynamic, quantitative MRI methods offer sensitive detection of endothelial dysfunction.
  • These MRI techniques have the potential to complement clinical workups for cardiovascular diseases.
  • Further validation may lead to routine clinical use for treatment strategy and efficacy evaluation.