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Virtual Prism Adaptation Therapy: Protocol for Validation in Healthy Adults
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Prism Adaptation Deficits in Schizophrenia.

Lisa A Bartolomeo1, Yong-Wook Shin2, Hannah J Block3

  • 1Department of Psychological and Brain Sciences and Program in Neuroscience, Indiana University, Bloomington, IN.

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|March 19, 2020
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Schizophrenia (SZ) is linked to cerebellar dysfunction. This study found that individuals with SZ show impaired sensorimotor adaptation, indicating problems in cerebellar circuits.

Keywords:
cerebellummotor adaptationprism adaptationschizophrenia

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Area of Science:

  • Neuroscience
  • Psychiatry

Background:

  • Clinical and neurobehavioral evidence suggests cerebellar dysfunction in schizophrenia (SZ).
  • The cerebellum plays a crucial role in motor adaptation and visuomotor control.

Purpose of the Study:

  • To investigate cerebellar circuit function in schizophrenia using the prism adaptation motor task (PAT).
  • To determine if sensorimotor adaptation is impaired in individuals with SZ.

Main Methods:

  • Thirty-one individuals with SZ and 31 healthy controls completed the PAT.
  • Movement data were collected using motion-sensing technology during reaching tasks before, during, and after prism exposure.

Main Results:

  • The SZ group exhibited significant impairments in adaptation, post-adaptation, aftereffects, and reorientation compared to controls.
  • These deficits persisted even with visual feedback, suggesting a specific impairment in sensorimotor adaptation.

Conclusions:

  • Sensorimotor adaptation is impaired in schizophrenia.
  • These findings implicate disturbances in cerebellar circuits in the pathophysiology of SZ.