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Updated: Dec 26, 2025
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Cobalt-Catalyzed One-Step Access to Pyroquilon and C-7 Alkenylation of Indoline with Activated Alkenes Using Weakly
Shyam Kumar Banjare1, Pragati Biswal1, Ponneri Chandrababu Ravikumar1
1School of Chemical Sciences, National Institute of Science Education and Research (NISER), HBNI Bhubaneswar, Jatani, Odisha 752050, India.
Abstract:
A new strategy for the C(7)-H functionalization of indoline derivatives using first-row transition-metal cobalt has been demonstrated wherein the pivaloyl group acts as a weakly coordinating directing group. Biologically important pyroquilon (tetrahydropyroquinolinone) derivatives have been synthesized in a one-pot manner through selective C(7)-H functionalization and concomitant cyclization. In this process, aromatic C-H and amidic C-N bonds are cleaved, and new C-C and C-N bonds are formed in a step-economical fashion. Further, selective C(7)-H alkenylation of indoline derivatives has also been accomplished using activated alkenes by varying the reaction conditions.
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