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Zinc sulfide nanoparticle-decorated fibre mesh to enable localized H2S-amplified chemotherapy
Gang Wang1, Dong Cen, Zhaohui Ren
1State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, 310027, China. xiang.li@zju.edu.cn hgr@zju.edu.cn.
Chemical Communications (Cambridge, England)
|March 19, 2020
Abstract:
For the first time, we report the design and fabrication of a ZnS nanoparticle-decorated silica fibre mesh (ZnS@SiO2) for localized H2S-amplified chemotherapy. With incorporation of DOX, implanted ZnS@SiO2 fibres enable sufficient on-site drug dosage and intracellular H2S content, inducing significant in vitro and in vivo tumour inhibition.
