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Ferracyclic carbonyl complexes as anti-inflammatory agents
Mark A Wright1, Tyler Wooldridge, Maria A O'Connell
1Energy Materials Laboratory, School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK. joseph.wright@uea.ac.uk.
Chemical Communications (Cambridge, England)
|March 19, 2020
Summary
New iron(ii) complexes release carbon monoxide (CO) upon light exposure. Adding thioglucose enhances water solubility and CO release efficiency, with potential anti-inflammatory applications.
Area of Science:
- Organometallic Chemistry
- Photochemistry
- Medicinal Chemistry
Background:
- Ferracyclic iron(II) complexes with two carbon monoxide (CO) ligands were synthesized.
- These complexes are capable of releasing CO upon irradiation with visible light.
Purpose of the Study:
- To investigate the effect of thioglucose substitution on the properties of ferracyclic iron(II) complexes.
- To evaluate the photochemical and biological activities of the modified complexes.
Main Methods:
- Synthesis of ferracyclic iron(II) complexes using Fe(CO)4Br2 and 2-aminopyridine or 2-aminonaphthalene.
- Photochemical studies involving visible light irradiation to induce CO release.
- Modification of complexes by substituting a halide with thioglucose.
- Assessment of water solubility and quantum yield for CO release.
- Evaluation of anti-inflammatory activity using a TNF assay.
Main Results:
- The parent complexes release two CO molecules upon visible light irradiation.
- Thioglucose substitution significantly enhanced water solubility.
- Quantum yield for CO release increased approximately fivefold with thioglucose modification.
- The complexes demonstrated anti-inflammatory activity in a TNF assay under dark conditions.
Conclusions:
- Thioglucose functionalization is an effective strategy to improve the water solubility and photochemical CO release efficiency of ferracyclic iron(II) complexes.
- These modified complexes exhibit promising anti-inflammatory properties, suggesting potential therapeutic applications.
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