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Updated: Dec 26, 2025
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Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
Published on: June 4, 2020
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Usefulness of the thromboelastogram in children: correlation with habitual coagulation tests
Pablo Sepúlveda M1, Andrea Salgado U1, José Barriga G1
1Departamento de Pediatría, División de Pediatría, Facultad de Medicina, Pontificia Universidad Católica de Chile, Chile.
Revista Chilena De Pediatria
|March 19, 2020
Summary
Conventional coagulation tests show limited correlation with thromboelastogram (TEG) values in critically ill children. TEG offers distinct insights into hemostasis, crucial for managing coagulation status in intensive care units (ICUs).
Area of Science:
- Pediatric Intensive Care
- Hemostasis and Thrombosis
- Clinical Coagulation Diagnostics
Background:
- Standard coagulation tests offer incomplete hemostasis evaluation, missing critical cell interactions in critically ill patients.
- Viscoelastic assays like thromboelastogram (TEG) assess the complete coagulation process and are emerging as global coagulation tests.
Purpose of the Study:
- To investigate the correlation between conventional coagulation tests and TEG parameters in pediatric intensive care unit (ICU) patients.
Main Methods:
- Retrospective review of 238 TEGs from pediatric ICU patients with coagulation abnormalities.
- Correlation analysis between TEG parameters and standard coagulation tests (platelet count, fibrinogen, prothrombin time, activated partial thromboplastin time).
- TEG analysis using the TEG® 5000 Hemostasis System with a 4.5 ml blood sample.
Main Results:
- Analysis included 201 TEGs from 59 pediatric patients.
- A moderate to low correlation was observed between most TEG parameters and conventional coagulation tests.
- No significant correlation was found for clot lysis percentages or clot firmness.
Conclusions:
- Conventional coagulation tests demonstrate a low correlation with TEG findings in critically ill children.
- TEG provides unique and complementary information regarding the coagulation status of pediatric ICU patients, beyond standard tests.
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