Related Experiment Video
Updated: Dec 26, 2025
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Detection of Helicobacter pylori Infection and Antibiotic Resistance via Stool Quantitative Polymerase Chain Reaction Analysis
Published on: May 16, 2025
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[Protocolized referral to endoscopy and Helicobacter pylori detected in stools aimed to decrease endoscopy waiting
Luis Coppelli1, Luis Antonio Díaz2, Arnoldo Riquelme2
1Unidad de Endoscopia, Hospital de Villarrica, Villarrica, Chile.
Revista Medica De Chile
|March 19, 2020
Summary
Implementing standardized endoscopy referrals and Helicobacter pylori stool antigen (HPSA) testing significantly reduced wait times and improved early gastric cancer detection in Chile.
Area of Science:
- Gastroenterology
- Oncology
- Public Health
Background:
- Chile faces high gastric cancer (GC) mortality rates globally.
- Primary prevention and early detection of GC and its precursor lesions are critical national health priorities.
Purpose of the Study:
- To evaluate the effectiveness of protocolized endoscopy referrals and H. pylori stool antigen (HPSA) testing in managing dyspepsia.
- To assess the impact on endoscopy waiting lists and the detection rates of gastric pre-neoplastic and early neoplastic lesions.
Main Methods:
- A study involving 4,641 endoscopies and 2,631 HPSA tests was conducted from January 2015 to December 2017.
- Protocols were implemented for dyspepsia referrals, incorporating HPSA testing to prioritize high-risk patients for endoscopy.
Main Results:
- Endoscopy waiting times decreased by 52% after protocol implementation.
- The early gastric cancer detection rate significantly increased from 0% in 2015 to 13% in 2017 (p = 0.03).
Conclusions:
- Protocolized endoscopy referrals combined with HPSA testing are effective strategies for reducing endoscopy waitlists.
- These integrated approaches optimize the detection of pre-neoplastic lesions and early-stage gastric cancer.
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