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Updated: Dec 26, 2025

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Differences in White Matter Microstructure Among Children With Developmental Coordination Disorder.

Meisan Brown-Lum^1,2, Sara Izadi-Najafabadi^1,2, Tim F Oberlander^2,3,4

¹Graduate Program in Rehabilitation Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

JAMA Network Open

|March 19, 2020

Summary

This summary is machine-generated.

Children with developmental coordination disorder (DCD) exhibit distinct white matter differences in motor pathways. These findings suggest potential disruptions in axonal development, offering new insights into this neurodevelopmental disorder.

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

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Published on: July 28, 2013

Area of Science:

Neuroscience
Developmental Pediatrics
Radiology

Background:

Developmental coordination disorder (DCD) is a motor impairment affecting daily activities, with unknown causes and developmental trajectories.
Understanding DCD's origins is crucial for effective interventions to improve motor function in affected children.

Purpose of the Study:

To investigate and characterize white matter microstructural differences in children with and without DCD using diffusion tensor imaging (DTI).

Main Methods:

A cross-sectional study involving 62 children (8-12 years old), comparing 31 with DCD and 30 without.
Diffusion tensor imaging (DTI) was used to measure white matter microstructure via fractional anisotropy (FA) and diffusivity parameters.
Tract-based spatial statistics (TBSS) were employed for voxelwise analysis, comparing DTI metrics between the two groups, controlling for age and attention.

Main Results:

Children with DCD showed significantly lower fractional anisotropy (FA) and axial diffusivity in motor and sensorimotor pathways, including the corticospinal tract and cerebellar pathways.
Specific regions like the posterior thalamic radiation also exhibited altered axial diffusivity in children with DCD.
No significant differences in mean diffusivity or radial diffusivity were observed between the groups.

Conclusions:

Children with DCD present with significant white matter differences in key motor and sensorimotor pathways compared to neurotypical peers.
The observed diffusion parameter patterns suggest potential disruptions in axonal development, contributing to the neurodevelopmental aspects of DCD.