Related Experiment Video
Updated: Aug 14, 2026
06:39
Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Depression and SSRI Treatment During Pregnancy-Prioritizing Maternal Mental Health
Katherine L Wisner1, Tim F Oberlander2, Lauren M Osborne3
1Departments of Psychiatry and Pediatrics, Developing Brain Institute, Children's National Hospital, and Obstetrics and Gynecology, George Washington University School of Medicine, Washington, DC.
JAMA Psychiatry
|August 12, 2026
Summary
Selective serotonin reuptake inhibitors (SSRI) are crucial for treating major depressive disorder (MDD) in pregnant patients. Evidence suggests SSRI use during pregnancy carries minimal risk, prioritizing maternal and infant health.
Area of Science:
- Perinatal mental health
- Psychiatry
- Obstetrics
Background:
- Major depressive disorder (MDD) affects 12% of pregnant patients, posing risks to maternal and infant well-being.
- Psychiatric conditions are a significant cause of maternal morbidity and mortality.
- Selective serotonin reuptake inhibitors (SSRI) are vital for managing perinatal MDD.
Purpose of the Study:
- To evaluate the safety and benefits of SSRI treatment during pregnancy.
- To inform clinical decision-making regarding perinatal MDD management.
- To highlight the importance of treating maternal depression for dual-generation health.
Main Methods:
- Review of existing studies on SSRI use in pregnancy.
- Analysis of confounding factors in observational studies.
- Synthesis of evidence on risks and benefits of SSRI treatment versus untreated MDD.
Main Results:
- SSRI treatment for moderate to severe MDD in pregnancy can prevent adverse effects associated with discontinuation.
- After accounting for confounding factors, SSRI use in pregnancy shows little to no risk of serious adverse outcomes.
- The focus is shifting towards prioritizing MDD treatment to optimize maternal health.
Conclusions:
- Treating perinatal MDD is essential for improving outcomes for both mother and infant.
- Expanding access to perinatal mental health care is a public health priority.
- A structured approach is needed to discuss risks and benefits of SSRI treatment with pregnant patients.
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