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Updated: Dec 26, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Left Bundle Branch Block: Current and Future Perspectives.

Nicholas Y Tan1, Chance M Witt1, Jae K Oh1

  • 1Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.

Circulation. Arrhythmia and Electrophysiology
|March 19, 2020
PubMed
Summary
This summary is machine-generated.

Left bundle branch block (LBBB) stems from heart issues or valve disease. Cardiac resynchronization therapy offers benefits for heart failure patients with LBBB, with new pacing methods emerging.

Keywords:
aortic valveatrioventricular nodecardiac resynchronization therapyheart failure

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Area of Science:

  • Cardiology
  • Electrophysiology

Background:

  • Left bundle branch block (LBBB) can result from conduction system degeneration or myocardial pathology.
  • It may also occur after aortic valve disease or cardiac procedures.

Purpose of the Study:

  • To review the pathophysiology and clinical aspects of LBBB.
  • To summarize current and future management strategies for LBBB.

Main Methods:

  • Literature review focusing on LBBB causes, clinical implications, and treatment options.
  • Discussion of cardiac resynchronization therapy (CRT) and emerging pacing techniques.

Main Results:

  • LBBB has diverse etiologies including degenerative and pathological causes.
  • CRT is a key therapy for heart failure with reduced ejection fraction and LBBB.
  • Coronary sinus lead placement is standard for CRT, but alternatives are under investigation.

Conclusions:

  • Understanding LBBB's origins is crucial for patient management.
  • CRT can improve outcomes in select heart failure patients with LBBB.
  • Ongoing research explores advanced pacing strategies for LBBB management.