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SUMOylation in development and neurodegeneration

Tak-Yu Yau1, Oscar Molina1, Albert J Courey2

  • 1Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095-1569, USA.

Development (Cambridge, England)
|March 20, 2020
PubMed
Summary

Small ubiquitin-related modifier (SUMO)ylation is a crucial protein modification in eukaryotes, impacting development, signal transduction, and gene transcription. This process is also implicated in neurodegenerative diseases and may promote neuronal stem cell survival.

Keywords:
EpigeneticsNeurodegenerative disorderPost-translational protein modificationSUMOSignal transductionUbiquitin-like protein

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